Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2155103..2155749 Replicon chromosome
Accession NZ_AP022372
Organism Providencia rettgeri strain BML2526

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag pBML2531_RS09780 Protein ID WP_004905417.1
Coordinates 2155103..2155306 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D4C184
Locus tag pBML2531_RS09785 Protein ID WP_004905413.1
Coordinates 2155381..2155749 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
pBML2531_RS09755 2151179..2151517 + 339 WP_004905421.1 P-II family nitrogen regulator -
pBML2531_RS09760 2151528..2152814 + 1287 WP_004905420.1 ammonium transporter AmtB -
pBML2531_RS09765 2152953..2153822 - 870 WP_036958583.1 acyl-CoA thioesterase II -
pBML2531_RS09770 2154061..2154519 + 459 WP_004905418.1 YbaY family lipoprotein -
pBML2531_RS09780 2155103..2155306 - 204 WP_004905417.1 hemolysin expression modulator Hha Toxin
pBML2531_RS09785 2155381..2155749 - 369 WP_004905413.1 Hha toxicity modulator TomB Antitoxin
pBML2531_RS09790 2156273..2157643 - 1371 WP_094962148.1 murein transglycosylase D -
pBML2531_RS09795 2157725..2158480 - 756 WP_004905408.1 hydroxyacylglutathione hydrolase -
pBML2531_RS09800 2158521..2159255 + 735 WP_094962149.1 methyltransferase domain-containing protein -
pBML2531_RS09805 2159252..2159722 - 471 WP_004905405.1 ribonuclease HI -
pBML2531_RS09810 2159777..2160538 + 762 WP_094962150.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T35489 WP_004905417.1 NZ_AP022372:c2155306-2155103 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T35489 NZ_AP022372:c2155306-2155103 [Providencia rettgeri]
ATGACCAAATCTGATTATCTGATGCGTTTAAGAAAATGCACCACAATTGAAACACTTGAGCGTGTCATTGAAAAAAATAA
GTATGAATTATCTGATGATGAGCTAGAGCTATTCTATTCAGCAGCAGATCACCGCTTAGCTGAACTCACAATGAATAAGC
TTTATGATAAAATCCCAGCGTCTGTTTGGAAGTTTGTTAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14085.04 Da        Isoelectric Point: 4.4915

>AT35489 WP_004905413.1 NZ_AP022372:c2155749-2155381 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNHSLVAVLDDDLKCLTSKT

Download         Length: 369 bp

>AT35489 NZ_AP022372:c2155749-2155381 [Providencia rettgeri]
ATGGATGAATACTCACCCAAAAGACATGATATAGCAGAACTAAAATACTTATGTAATAGTCTCAATAGAGACGCTATTTT
AAGCTTACAAAAAACAAATACACACTGGATTAATGATTTAAGCTCCCCGCAAAGCGCAGCCTTGAATGAACTCATTGAAC
ATATCGCTGCATTTGTATGGCGGTTTAAAATCAAATACCCAAAAGAAAATCTTGTTATATCACTTATCGAAGAATACCTC
GATGAGACCTATGATTTATTCGGCAGCCCAGTTATCACACTTAGTGAAATTATAGACTGGGAAGCAATGAATCACAGCCT
TGTCGCTGTGCTGGATGATGACCTAAAGTGCCTAACCAGCAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q6D9

References