Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4644453..4646029 Replicon chromosome
Accession NZ_AP022371
Organism Providencia rettgeri strain BML2496

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag G7Y72_RS21515 Protein ID WP_164561278.1
Coordinates 4644453..4645772 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag G7Y72_RS21520 Protein ID WP_036959176.1
Coordinates 4645772..4646029 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y72_RS21505 4640390..4643437 - 3048 WP_096863650.1 formate dehydrogenase-N subunit alpha -
G7Y72_RS21510 4643612..4644442 + 831 WP_036959175.1 formate dehydrogenase accessory sulfurtransferase FdhD -
G7Y72_RS21515 4644453..4645772 - 1320 WP_164561278.1 type II toxin-antitoxin system HipA family toxin Toxin
G7Y72_RS21520 4645772..4646029 - 258 WP_036959176.1 helix-turn-helix domain-containing protein Antitoxin
G7Y72_RS21525 4646352..4647716 - 1365 WP_096863651.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
G7Y72_RS21530 4647818..4649467 - 1650 WP_094961982.1 membrane protein insertase YidC -
G7Y72_RS21535 4649470..4649730 - 261 WP_036959180.1 membrane protein insertion efficiency factor YidD -
G7Y72_RS21540 4649694..4650053 - 360 WP_004906229.1 ribonuclease P protein component -
G7Y72_RS21545 4650075..4650218 - 144 WP_004906236.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 50036.04 Da        Isoelectric Point: 6.6933

>T35486 WP_164561278.1 NZ_AP022371:c4645772-4644453 [Providencia rettgeri]
MATLHVYMNGYLVGDLIRSSTGAHQFTYNSHWLETSGARPISLSMPLRHQEYRGDEVYNFFDNLLPDNIEIRNRIVSRYQ
ADSNQPFDLLSKIGQDSVGALQLILDGQRVSNIRKIEYKPLSNKQLEKILTGYKANAPLGMIEDEDDFRISLAGAQEKTA
LLYLDGHWCLPQNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKEFGLDVPRSFILNVGEIKALAVERFDRK
YSSDSSWIMRLPQEDFCQTLNISPARKYQNHGGPGISEIMNYLLGSINTEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
EPEGRYQLTPFYDILSMYPSYGGRGINPRDAKLAMGLKGTRGMKYNIEQIFPRHFFSTAKAVGFDRAEMEKILIEFGEQM
ESVIKKVREQLPTDFPEHIADSILSGLHHKAARLNKGWD

Download         Length: 1320 bp

>T35486 NZ_AP022371:c4645772-4644453 [Providencia rettgeri]
ATGGCGACTTTGCATGTATACATGAATGGTTACTTGGTTGGGGATTTGATTCGTTCAAGTACTGGTGCTCACCAATTTAC
ATATAATAGTCACTGGTTGGAAACATCAGGTGCTCGACCTATTTCTTTATCAATGCCACTTAGGCACCAAGAATATCGAG
GAGACGAAGTTTATAATTTTTTTGATAATCTCCTACCGGACAATATTGAGATACGGAATCGAATTGTTAGTCGTTATCAA
GCGGATTCAAATCAACCTTTCGATTTATTATCTAAGATTGGCCAGGATAGTGTGGGGGCTTTACAACTCATTCTAGATGG
GCAAAGAGTCAGTAATATCAGAAAAATTGAATATAAACCCTTATCTAATAAGCAACTAGAAAAAATATTAACAGGGTATA
AAGCGAATGCTCCTTTAGGCATGATTGAAGATGAAGATGACTTTAGGATCTCACTTGCGGGCGCTCAAGAGAAAACCGCA
TTACTCTATTTAGATGGGCATTGGTGCTTACCTCAGAATGCGACTCCAACTACCCATATTATTAAACTTCCCATTGGTAA
AATAGAAAGCCATTCTTATTCGATAGATATGTCGGATAGTGTAGAAAATGAGTATTTATGTTTATTGATAGCAAAAGAGT
TTGGCCTAGATGTGCCTCGTAGCTTTATTTTAAATGTAGGTGAAATAAAGGCGTTAGCGGTTGAACGTTTTGACCGTAAA
TATTCTTCTGATTCCTCGTGGATTATGCGTTTACCACAAGAAGATTTTTGTCAAACATTGAATATTTCACCAGCAAGAAA
ATATCAAAATCATGGTGGACCGGGTATTTCTGAAATTATGAATTACTTATTGGGTTCAATAAATACAGAGAAAGATAGAT
ATCAGTTTATGAAGAGCCAAGTTTTGTTCTGGCTACTTGCAGCGACGGATGGTCATGCTAAAAATTTTTCATTATTTATT
GAACCTGAAGGCCGTTATCAGTTAACACCTTTTTACGATATTTTGTCCATGTATCCTAGTTATGGGGGGAGGGGAATTAA
CCCTAGAGATGCCAAATTGGCTATGGGGCTGAAGGGAACAAGGGGGATGAAATACAATATAGAGCAAATTTTCCCAAGAC
ATTTTTTTTCAACGGCCAAAGCCGTTGGATTTGATCGTGCTGAGATGGAAAAAATCTTAATTGAATTTGGTGAGCAAATG
GAAAGTGTTATTAAGAAAGTGAGAGAACAATTACCCACAGATTTCCCTGAGCATATCGCAGACTCAATTCTATCCGGATT
ACATCACAAAGCAGCGAGATTAAATAAAGGCTGGGACTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9628.85 Da        Isoelectric Point: 9.6898

>AT35486 WP_036959176.1 NZ_AP022371:c4646029-4645772 [Providencia rettgeri]
MKVTNTRQLSAYMKDVRETKKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNSDSG
WKEEW

Download         Length: 258 bp

>AT35486 NZ_AP022371:c4646029-4645772 [Providencia rettgeri]
ATGAAAGTGACGAATACCCGACAACTTAGTGCTTATATGAAGGATGTCAGAGAGACGAAAAAGTTATCTCAAAGCAAAGT
CGCTAGTAAAGTAGGTATTCGGCAAGATACTGTTTCTAGCTTTGAACTCTCTCCTGACTCTACCAAATTAGAAACCTTTT
TTAAGATTTTATCTGCCCTCAATTTAGAACTCGATATTAAACCGCGAAATGAAAGTGGCTCATCAAATTCAGACTCCGGA
TGGAAGGAGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References