Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 4533403..4533986 Replicon chromosome
Accession NZ_AP022371
Organism Providencia rettgeri strain BML2496

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag G7Y72_RS20990 Protein ID WP_096863599.1
Coordinates 4533684..4533986 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G7Y72_RS20985 Protein ID WP_004265229.1
Coordinates 4533403..4533687 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y72_RS20960 4528563..4529540 - 978 WP_004265237.1 6-phosphofructokinase -
G7Y72_RS20965 4529947..4530891 - 945 WP_004265235.1 phosphatidate cytidylyltransferase -
G7Y72_RS20970 4530888..4531529 - 642 WP_096863597.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
G7Y72_RS20975 4531767..4532519 - 753 WP_004265231.1 M48 family metallopeptidase -
G7Y72_RS20980 4532739..4533320 - 582 WP_164561267.1 HutD family protein -
G7Y72_RS20985 4533403..4533687 - 285 WP_004265229.1 putative addiction module antidote protein Antitoxin
G7Y72_RS20990 4533684..4533986 - 303 WP_096863599.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7Y72_RS20995 4534243..4534812 - 570 WP_096863600.1 Spy/CpxP family protein refolding chaperone -
G7Y72_RS21000 4534963..4535661 + 699 WP_004265224.1 envelope stress response regulator transcription factor CpxR -
G7Y72_RS21005 4535658..4537028 + 1371 WP_164561268.1 envelope stress sensor histidine kinase CpxA -
G7Y72_RS21010 4537500..4538936 + 1437 WP_096863601.1 capsule assembly Wzi family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11433.37 Da        Isoelectric Point: 10.0723

>T35485 WP_096863599.1 NZ_AP022371:c4533986-4533684 [Providencia rettgeri]
MITVLTTECFDSWIKNLRDIRAKTKILMRIRRLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKNNVIVILLCGGTKA
TQQKDIHKAKLLFGEVEGEL

Download         Length: 303 bp

>T35485 NZ_AP022371:c4533986-4533684 [Providencia rettgeri]
ATGATCACGGTTCTAACAACGGAATGTTTTGATAGTTGGATCAAAAATCTTAGAGATATTCGAGCTAAAACTAAAATTCT
AATGAGAATTAGGCGGTTAAAAAATGGAAATTATGGTGATGTTCAACCCATTGGTGATGGCTTTTCGGAACTGAGGGTAC
ATGAAGGACAAGGGTATCGTGTTTATCTAAAGCAGAAAAACAATGTTATTGTAATTTTACTTTGTGGTGGGACAAAGGCA
ACGCAGCAGAAGGATATCCATAAAGCTAAACTCCTTTTTGGTGAAGTTGAGGGGGAACTATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10454.13 Da        Isoelectric Point: 4.5983

>AT35485 WP_004265229.1 NZ_AP022371:c4533687-4533403 [Providencia rettgeri]
MNTKLKEFDIAEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Download         Length: 285 bp

>AT35485 NZ_AP022371:c4533687-4533403 [Providencia rettgeri]
ATGAATACTAAATTAAAAGAATTTGATATCGCTGAGTATTTAAACAGTGAAGAAGAAATACAAATGTATCTAAACGAAAT
TCTAGAAGAAGGTGACCCTAGTCTAGTTCTCGCTGCACTTGGTGATATTGCGAAGGCAAGAAATATGAGCCAATTAGCTA
AAGAAGTTGGAATGAGTCGTGAAGGTTTATATAAGGCACTATCAGGACAGGGAAATCCAACATTTATGACGATTATAAAA
ATCGTTAATTCTCTCGGATTAAAGCTACAGTTTAAGAGTATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References