Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2961377..2962034 Replicon chromosome
Accession NZ_AP022371
Organism Providencia rettgeri strain BML2496

Toxin (Protein)


Gene name cptA Uniprot ID A0A264VM08
Locus tag G7Y72_RS13860 Protein ID WP_036958456.1
Coordinates 2961377..2961787 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4C097
Locus tag G7Y72_RS13865 Protein ID WP_004261864.1
Coordinates 2961768..2962034 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y72_RS13840 2957270..2959003 - 1734 WP_096863167.1 single-stranded-DNA-specific exonuclease RecJ -
G7Y72_RS13845 2959013..2959717 - 705 WP_096863312.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G7Y72_RS13850 2959739..2960641 - 903 WP_004261814.1 site-specific tyrosine recombinase XerD -
G7Y72_RS13855 2960759..2961277 + 519 WP_004261816.1 flavodoxin FldB -
G7Y72_RS13860 2961377..2961787 - 411 WP_036958456.1 protein YgfX Toxin
G7Y72_RS13865 2961768..2962034 - 267 WP_004261864.1 FAD assembly factor SdhE Antitoxin
G7Y72_RS13870 2962282..2963265 + 984 WP_164561167.1 tRNA-modifying protein YgfZ -
G7Y72_RS13875 2963277..2963897 + 621 WP_096863168.1 HD domain-containing protein -
G7Y72_RS13880 2964141..2965037 + 897 WP_164561168.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15568.53 Da        Isoelectric Point: 10.7733

>T35482 WP_036958456.1 NZ_AP022371:c2961787-2961377 [Providencia rettgeri]
VVLWKSNLSISWKTQLFSTCVHGVIGMFLLLAPWSPGNSMIWLPLLVVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWRILKAPWLTRYGILLTLEALQGKPQKLHLWVAKDALSEENWRNLNQLLLQYPDI

Download         Length: 411 bp

>T35482 NZ_AP022371:c2961787-2961377 [Providencia rettgeri]
GTGGTCCTGTGGAAATCTAATCTCTCCATTTCATGGAAAACCCAACTGTTCTCAACCTGTGTTCATGGGGTCATTGGGAT
GTTTTTACTATTGGCTCCATGGTCCCCTGGTAACTCAATGATATGGTTGCCGCTATTAGTGGTTGTCGTTGCGAGTTGGG
CAAAGAGCCAGAAAAATATCAGTAAAATAAAAGGGGTTGCTGTACTGGTTAATGGCAATAAGGTTCAGTGGAAGAAAAAT
GAATGGAGAATACTGAAAGCACCTTGGCTTACCCGCTATGGTATATTACTGACACTAGAAGCGTTACAAGGTAAACCACA
AAAGCTCCATTTGTGGGTTGCAAAAGACGCATTGTCGGAAGAGAATTGGCGTAATTTAAACCAATTATTGCTGCAATATC
CGGATATTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10684.24 Da        Isoelectric Point: 4.8942

>AT35482 WP_004261864.1 NZ_AP022371:c2962034-2961768 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDDLTTHDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMIKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT35482 NZ_AP022371:c2962034-2961768 [Providencia rettgeri]
ATGGATATTGAGAATAAAGCGCGAATTCATTGGGCATGCCGCCGTGGTATGCGTGAATTAGATATTTCAATCATGCCGTT
TTTTGAGTATGAATATGATGACCTAACAACTCACGATAAGCAGGTATTTGTCCGTTTATTAGAATGTGCGGACCCTGATT
TATTCAATTGGCTAATGAATCACGGTCGTCCAGATGATGACGAACTTTTTCGTATGATTAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A264VM08

Antitoxin

Source ID Structure
AlphaFold DB A0A345M2Q5

References