Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2683954..2684602 Replicon chromosome
Accession NZ_AP022371
Organism Providencia rettgeri strain BML2496

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G7Y72_RS12575 Protein ID WP_096863453.1
Coordinates 2683954..2684139 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G7Y72_RS12580 Protein ID WP_094961723.1
Coordinates 2684189..2684602 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y72_RS12555 2679828..2680916 - 1089 WP_094961726.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -
G7Y72_RS12560 2680919..2681779 - 861 WP_004264881.1 sulfate/thiosulfate ABC transporter permease CysW -
G7Y72_RS12565 2681779..2682609 - 831 WP_004264883.1 sulfate/thiosulfate ABC transporter permease CysT -
G7Y72_RS12570 2682609..2683631 - 1023 WP_094961725.1 sulfate ABC transporter substrate-binding protein -
G7Y72_RS12575 2683954..2684139 + 186 WP_096863453.1 type II toxin-antitoxin system HicA family toxin Toxin
G7Y72_RS12580 2684189..2684602 + 414 WP_094961723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G7Y72_RS12585 2684668..2685567 - 900 WP_096863452.1 Dyp-type peroxidase -
G7Y72_RS12590 2685815..2686420 - 606 WP_050763802.1 RpoE-regulated lipoprotein -
G7Y72_RS12595 2686512..2686943 - 432 WP_004264887.1 GNAT family acetyltransferase -
G7Y72_RS12600 2687080..2687997 + 918 WP_004264888.1 oxygen-dependent coproporphyrinogen oxidase -
G7Y72_RS12605 2688156..2689292 + 1137 WP_036958991.1 M4 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6965.13 Da        Isoelectric Point: 10.9186

>T35481 WP_096863453.1 NZ_AP022371:2683954-2684139 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLTH

Download         Length: 186 bp

>T35481 NZ_AP022371:2683954-2684139 [Providencia rettgeri]
GTGCAAAGTTCGGAACTGATAAACATACTGCAAAAAAACGGTTGGAAACTTGAAAGAATAAAAGGAAGTCACCATCAGTT
TTCCCACCCACATTTTTCAATTGTAATTACTGTTCCGCATCCACAAAAAGATTTAAAGATAGGCACACTAAATCACATTT
TGAAGGCTGCGAAACTAACACATTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15362.31 Da        Isoelectric Point: 4.6719

>AT35481 WP_094961723.1 NZ_AP022371:2684189-2684602 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAAAARKELKKTD

Download         Length: 414 bp

>AT35481 NZ_AP022371:2684189-2684602 [Providencia rettgeri]
ATGCTTTATACCGCCTTTATTGAAATTGATAATGATGGCAGCGCAAGTGGCTGGTTTCCTGATATTGAAGGATGTACATT
CGCGGGCAGCAATATAGAAGAGGCTTACGCAGAAGCAAAATCAGCAATTGATGCTCATTTTGAATTATTGAGTGAAAAAG
GCTTTGAGATCCCATTATCGAAATCTCAGCAAACGCTATTGAACCCAATACAACCTGAATATGCGCATGGGATATGGTTA
TTTGTGGATGTCGATATGGATAAATACGATGGCCGTACTGAGCGTATTAATATCACCTTGCCGCATCGTTTATTACATCG
TATTGATGCTTTAGTGAAGGTTAATCCTGAATATGGTAGCCGTAGTGGTTTTATTGCTGCTGCAGCTCGTAAAGAATTAA
AAAAAACCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References