Detailed information of TA system TA035481

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2683954..2684602
• Replicon: chromosome
• Accession: NZ_AP022371
• Organism: Providencia rettgeri strain BML2496

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: G7Y72_RS12575
• Protein ID: WP_096863453.1
• Coordinates: 2683954..2684139 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: G7Y72_RS12580
• Protein ID: WP_094961723.1
• Coordinates: 2684189..2684602 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7Y72_RS12555	2679828..2680916	-	1089	WP_094961726.1	sulfate/thiosulfate ABC transporter ATP-binding protein CysA	-
G7Y72_RS12560	2680919..2681779	-	861	WP_004264881.1	sulfate/thiosulfate ABC transporter permease CysW	-
G7Y72_RS12565	2681779..2682609	-	831	WP_004264883.1	sulfate/thiosulfate ABC transporter permease CysT	-
G7Y72_RS12570	2682609..2683631	-	1023	WP_094961725.1	sulfate ABC transporter substrate-binding protein	-
G7Y72_RS12575	2683954..2684139	+	186	WP_096863453.1	type II toxin-antitoxin system HicA family toxin	Toxin
G7Y72_RS12580	2684189..2684602	+	414	WP_094961723.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
G7Y72_RS12585	2684668..2685567	-	900	WP_096863452.1	Dyp-type peroxidase	-
G7Y72_RS12590	2685815..2686420	-	606	WP_050763802.1	RpoE-regulated lipoprotein	-
G7Y72_RS12595	2686512..2686943	-	432	WP_004264887.1	GNAT family acetyltransferase	-
G7Y72_RS12600	2687080..2687997	+	918	WP_004264888.1	oxygen-dependent coproporphyrinogen oxidase	-
G7Y72_RS12605	2688156..2689292	+	1137	WP_036958991.1	M4 family metallopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6965.13 Da
• Isoelectric Point: 10.9186

>T35481 WP_096863453.1 NZ_AP022371:2683954-2684139 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLTH

Nucleotide

• Length: 186 bp

>T35481 NZ_AP022371:2683954-2684139 [Providencia rettgeri]
GTGCAAAGTTCGGAACTGATAAACATACTGCAAAAAAACGGTTGGAAACTTGAAAGAATAAAAGGAAGTCACCATCAGTT
TTCCCACCCACATTTTTCAATTGTAATTACTGTTCCGCATCCACAAAAAGATTTAAAGATAGGCACACTAAATCACATTT
TGAAGGCTGCGAAACTAACACATTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15362.31 Da
• Isoelectric Point: 4.6719

>AT35481 WP_094961723.1 NZ_AP022371:2684189-2684602 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAAAARKELKKTD

Nucleotide

• Length: 414 bp

>AT35481 NZ_AP022371:2684189-2684602 [Providencia rettgeri]
ATGCTTTATACCGCCTTTATTGAAATTGATAATGATGGCAGCGCAAGTGGCTGGTTTCCTGATATTGAAGGATGTACATT
CGCGGGCAGCAATATAGAAGAGGCTTACGCAGAAGCAAAATCAGCAATTGATGCTCATTTTGAATTATTGAGTGAAAAAG
GCTTTGAGATCCCATTATCGAAATCTCAGCAAACGCTATTGAACCCAATACAACCTGAATATGCGCATGGGATATGGTTA
TTTGTGGATGTCGATATGGATAAATACGATGGCCGTACTGAGCGTATTAATATCACCTTGCCGCATCGTTTATTACATCG
TATTGATGCTTTAGTGAAGGTTAATCCTGAATATGGTAGCCGTAGTGGTTTTATTGCTGCTGCAGCTCGTAAAGAATTAA
AAAAAACCGATTAA