Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1467111..1467646 Replicon chromosome
Accession NZ_AP022371
Organism Providencia rettgeri strain BML2496

Toxin (Protein)


Gene name ccdB Uniprot ID D4BV22
Locus tag G7Y72_RS06650 Protein ID WP_004255694.1
Coordinates 1467111..1467419 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID D4BV21
Locus tag G7Y72_RS06655 Protein ID WP_004255691.1
Coordinates 1467419..1467646 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y72_RS06620 1463091..1463927 + 837 WP_164561293.1 chemotaxis protein-glutamate O-methyltransferase -
G7Y72_RS06625 1463927..1464994 + 1068 WP_094961164.1 chemotaxis response regulator protein-glutamate methylesterase -
G7Y72_RS06630 1465036..1465428 + 393 WP_004255705.1 chemotaxis response regulator CheY -
G7Y72_RS06635 1465453..1466091 + 639 WP_004255702.1 protein phosphatase CheZ -
G7Y72_RS06640 1466262..1466495 + 234 WP_080544466.1 helix-turn-helix domain-containing protein -
G7Y72_RS06645 1466538..1467095 - 558 WP_096864709.1 hypothetical protein -
G7Y72_RS06650 1467111..1467419 - 309 WP_004255694.1 CcdB family protein Toxin
G7Y72_RS06655 1467419..1467646 - 228 WP_004255691.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
G7Y72_RS06660 1467910..1469061 + 1152 WP_004255688.1 flagellar type III secretion system protein FlhB -
G7Y72_RS06665 1469054..1471153 + 2100 WP_004255687.1 flagellar biosynthesis protein FlhA -
G7Y72_RS06670 1471386..1471664 + 279 WP_004255684.1 helix-turn-helix domain-containing protein -
G7Y72_RS06675 1471711..1472151 - 441 WP_096864710.1 flagellar export chaperone FlgN -
G7Y72_RS06680 1472161..1472463 - 303 WP_096864711.1 anti-sigma-28 factor FlgM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(5-75)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11763.84 Da        Isoelectric Point: 7.2408

>T35479 WP_004255694.1 NZ_AP022371:c1467419-1467111 [Providencia rettgeri]
MQYCLYQNREDTVKYPYLLDIQSNIIDILNTRLVIPLFDSRLVKKPLPVRLNPQLSINGQVFILMTHQMACVPHSLLGKE
IVDLSSQRDTIKHAIDLLIDGF

Download         Length: 309 bp

>T35479 NZ_AP022371:c1467419-1467111 [Providencia rettgeri]
ATGCAATATTGCCTCTATCAAAACCGAGAAGATACGGTCAAATACCCATATTTACTGGATATTCAAAGTAACATTATTGA
TATATTGAATACTCGTTTAGTCATCCCGTTATTCGATAGCAGGCTAGTTAAAAAGCCATTACCTGTACGCTTAAATCCAC
AATTATCAATCAACGGGCAGGTTTTTATTTTAATGACTCACCAAATGGCTTGCGTCCCTCATTCATTATTAGGGAAAGAA
ATCGTTGACTTAAGTAGCCAACGAGACACCATTAAACACGCAATTGACTTACTGATTGATGGCTTTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8688.92 Da        Isoelectric Point: 8.9375

>AT35479 WP_004255691.1 NZ_AP022371:c1467646-1467419 [Providencia rettgeri]
MNRTKKTVSVTVAPELYEQARRAKLNLSAILACALQAELKRLEAQKWKNDNVEGFNELNRINEEYGLLSDKYKDF

Download         Length: 228 bp

>AT35479 NZ_AP022371:c1467646-1467419 [Providencia rettgeri]
ATGAACAGAACAAAAAAAACCGTCAGTGTCACTGTCGCGCCTGAACTCTACGAACAAGCAAGGCGGGCTAAACTTAACTT
ATCAGCAATACTGGCTTGTGCCTTACAAGCTGAATTAAAACGCCTCGAAGCGCAAAAATGGAAAAATGACAATGTCGAAG
GCTTTAATGAGTTAAACAGGATAAATGAAGAATATGGATTACTCTCAGATAAATACAAGGATTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4BV22

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q922

References