Detailed information of TA system TA035477

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 245318..246071
• Replicon: chromosome
• Accession: NZ_AP022371
• Organism: Providencia rettgeri strain BML2496

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: G7Y72_RS01055
• Protein ID: WP_096864327.1
• Coordinates: 245318..245752 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G7Y72_RS01060
• Protein ID: WP_004905885.1
• Coordinates: 245742..246071 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7Y72_RS01045	242241..243107	+	867	WP_004905888.1	lipoprotein NlpI	-
G7Y72_RS01050	243278..245209	+	1932	WP_164560869.1	DEAD/DEAH family ATP-dependent RNA helicase	-
G7Y72_RS01055	245318..245752	+	435	WP_096864327.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G7Y72_RS01060	245742..246071	+	330	WP_004905885.1	helix-turn-helix domain-containing protein	Antitoxin
G7Y72_RS01065	246076..246792	-	717	WP_004905884.1	two-component system response regulator BtsR	-
G7Y72_RS01070	246812..248497	-	1686	WP_004905883.1	sensor histidine kinase	-
G7Y72_RS01075	249031..250002	+	972	WP_004905881.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (19-139)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-93)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 16141.82 Da
• Isoelectric Point: 9.3330

>T35477 WP_096864327.1 NZ_AP022371:245318-245752 [Providencia rettgeri]
MALATIVIGTTWRVVVAFYKISSFKRSTKKIKIMDKHLLKAANEVLAGVYEADLGSGVIKKRIAINGKGKSGGVRVIIFF
KVSHHLFFADGWEKCNIAAKGVKEIEDDELDAYKNLSRLFLNYTDDKIADLVLHNILEELTDEQ

Nucleotide

• Length: 435 bp

>T35477 NZ_AP022371:245318-245752 [Providencia rettgeri]
ATGGCACTTGCTACTATAGTAATAGGTACTACATGGAGAGTAGTTGTGGCGTTCTATAAAATTTCCTCATTTAAGCGAAG
CACCAAAAAAATTAAGATAATGGATAAACACTTGCTTAAGGCTGCAAATGAAGTCTTAGCGGGGGTTTATGAAGCAGACT
TAGGAAGTGGTGTAATTAAAAAAAGGATTGCCATTAATGGAAAAGGGAAAAGTGGTGGGGTCAGGGTTATTATATTCTTC
AAAGTTAGCCATCATCTCTTTTTTGCCGATGGTTGGGAGAAATGCAATATAGCTGCTAAAGGAGTAAAAGAAATTGAAGA
TGATGAACTAGATGCGTATAAGAATTTATCTCGACTTTTTCTTAATTATACGGATGATAAAATTGCTGATTTAGTTTTAC
ATAATATTTTGGAGGAGCTTACTGATGAGCAATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12235.50 Da
• Isoelectric Point: 10.3803

>AT35477 WP_004905885.1 NZ_AP022371:245742-246071 [Providencia rettgeri]
MSNKLENMLELAKELHQVDAAPKSLVTDLEQKVGNRKINNKIKVVPMMSGAQIKQLRAQYGMSQAMLALALGMSKESVSK
WEREEKKPSGPALRMLHLIEQRGPEILII

Nucleotide

• Length: 330 bp

>AT35477 NZ_AP022371:245742-246071 [Providencia rettgeri]
ATGAGCAATAAACTAGAAAACATGCTTGAGCTAGCGAAAGAGTTACATCAGGTTGATGCTGCACCAAAAAGTTTAGTTAC
TGATTTAGAACAGAAGGTTGGTAATCGTAAAATAAATAATAAAATCAAGGTAGTACCTATGATGAGCGGTGCGCAAATCA
AACAACTCCGTGCTCAATATGGAATGTCACAAGCCATGTTAGCTTTAGCGCTGGGCATGTCTAAGGAAAGCGTATCTAAG
TGGGAAAGAGAAGAAAAAAAACCCAGTGGCCCAGCTCTAAGAATGCTACATCTTATAGAGCAGCGAGGGCCAGAGATTTT
AATTATTTAA