Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 245318..246071 Replicon chromosome
Accession NZ_AP022371
Organism Providencia rettgeri strain BML2496

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G7Y72_RS01055 Protein ID WP_096864327.1
Coordinates 245318..245752 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G7Y72_RS01060 Protein ID WP_004905885.1
Coordinates 245742..246071 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y72_RS01045 242241..243107 + 867 WP_004905888.1 lipoprotein NlpI -
G7Y72_RS01050 243278..245209 + 1932 WP_164560869.1 DEAD/DEAH family ATP-dependent RNA helicase -
G7Y72_RS01055 245318..245752 + 435 WP_096864327.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7Y72_RS01060 245742..246071 + 330 WP_004905885.1 helix-turn-helix domain-containing protein Antitoxin
G7Y72_RS01065 246076..246792 - 717 WP_004905884.1 two-component system response regulator BtsR -
G7Y72_RS01070 246812..248497 - 1686 WP_004905883.1 sensor histidine kinase -
G7Y72_RS01075 249031..250002 + 972 WP_004905881.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(19-139)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-93)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 16141.82 Da        Isoelectric Point: 9.3330

>T35477 WP_096864327.1 NZ_AP022371:245318-245752 [Providencia rettgeri]
MALATIVIGTTWRVVVAFYKISSFKRSTKKIKIMDKHLLKAANEVLAGVYEADLGSGVIKKRIAINGKGKSGGVRVIIFF
KVSHHLFFADGWEKCNIAAKGVKEIEDDELDAYKNLSRLFLNYTDDKIADLVLHNILEELTDEQ

Download         Length: 435 bp

>T35477 NZ_AP022371:245318-245752 [Providencia rettgeri]
ATGGCACTTGCTACTATAGTAATAGGTACTACATGGAGAGTAGTTGTGGCGTTCTATAAAATTTCCTCATTTAAGCGAAG
CACCAAAAAAATTAAGATAATGGATAAACACTTGCTTAAGGCTGCAAATGAAGTCTTAGCGGGGGTTTATGAAGCAGACT
TAGGAAGTGGTGTAATTAAAAAAAGGATTGCCATTAATGGAAAAGGGAAAAGTGGTGGGGTCAGGGTTATTATATTCTTC
AAAGTTAGCCATCATCTCTTTTTTGCCGATGGTTGGGAGAAATGCAATATAGCTGCTAAAGGAGTAAAAGAAATTGAAGA
TGATGAACTAGATGCGTATAAGAATTTATCTCGACTTTTTCTTAATTATACGGATGATAAAATTGCTGATTTAGTTTTAC
ATAATATTTTGGAGGAGCTTACTGATGAGCAATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12235.50 Da        Isoelectric Point: 10.3803

>AT35477 WP_004905885.1 NZ_AP022371:245742-246071 [Providencia rettgeri]
MSNKLENMLELAKELHQVDAAPKSLVTDLEQKVGNRKINNKIKVVPMMSGAQIKQLRAQYGMSQAMLALALGMSKESVSK
WEREEKKPSGPALRMLHLIEQRGPEILII

Download         Length: 330 bp

>AT35477 NZ_AP022371:245742-246071 [Providencia rettgeri]
ATGAGCAATAAACTAGAAAACATGCTTGAGCTAGCGAAAGAGTTACATCAGGTTGATGCTGCACCAAAAAGTTTAGTTAC
TGATTTAGAACAGAAGGTTGGTAATCGTAAAATAAATAATAAAATCAAGGTAGTACCTATGATGAGCGGTGCGCAAATCA
AACAACTCCGTGCTCAATATGGAATGTCACAAGCCATGTTAGCTTTAGCGCTGGGCATGTCTAAGGAAAGCGTATCTAAG
TGGGAAAGAGAAGAAAAAAAACCCAGTGGCCCAGCTCTAAGAATGCTACATCTTATAGAGCAGCGAGGGCCAGAGATTTT
AATTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References