Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4165965..4166799 Replicon chromosome
Accession NZ_AP022362
Organism Escherichia coli strain E302

Toxin (Protein)


Gene name yeeV Uniprot ID S1PLF5
Locus tag G6M96_RS20430 Protein ID WP_000854690.1
Coordinates 4166422..4166799 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P7N8
Locus tag G6M96_RS20425 Protein ID WP_001305076.1
Coordinates 4165965..4166333 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M96_RS20385 4161047..4162174 + 1128 Protein_3989 hypothetical protein -
G6M96_RS20390 4162250..4162705 + 456 WP_000581502.1 hypothetical protein -
G6M96_RS20395 4162784..4163017 + 234 WP_000902034.1 DUF905 family protein -
G6M96_RS20400 4163118..4163936 + 819 WP_001234620.1 DUF945 domain-containing protein -
G6M96_RS20405 4163991..4164476 + 486 WP_000849565.1 antirestriction protein -
G6M96_RS20410 4164492..4164968 + 477 WP_001186726.1 RadC family protein -
G6M96_RS20415 4165031..4165252 + 222 WP_000692329.1 DUF987 domain-containing protein -
G6M96_RS20420 4165271..4165915 + 645 WP_000094916.1 hypothetical protein -
G6M96_RS20425 4165965..4166333 + 369 WP_001305076.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G6M96_RS20430 4166422..4166799 + 378 WP_000854690.1 TA system toxin CbtA family protein Toxin
G6M96_RS20435 4166796..4167284 + 489 WP_000761699.1 hypothetical protein -
G6M96_RS20440 4167301..4167498 + 198 WP_000839293.1 DUF957 domain-containing protein -
G6M96_RS20445 4167583..4168428 + 846 WP_001529401.1 DUF4942 domain-containing protein -
G6M96_RS20450 4168497..4168892 + 396 WP_000208384.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
G6M96_RS20455 4168885..4169818 + 934 Protein_4003 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
G6M96_RS20460 4170250..4170405 + 156 WP_000729638.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4170250..4170405 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14057.04 Da        Isoelectric Point: 9.1510

>T35472 WP_000854690.1 NZ_AP022362:4166422-4166799 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T35472 NZ_AP022362:4166422-4166799 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13560.39 Da        Isoelectric Point: 4.7830

>AT35472 WP_001305076.1 NZ_AP022362:4165965-4166333 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT35472 NZ_AP022362:4165965-4166333 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PLF5


Antitoxin

Source ID Structure
AlphaFold DB S1P7N8

References