Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2968408..2969239 Replicon chromosome
Accession NZ_AP022351
Organism Escherichia coli strain E138

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag GR930_RS14585 Protein ID WP_000854814.1
Coordinates 2968865..2969239 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A641DSP2
Locus tag GR930_RS14580 Protein ID WP_001546021.1
Coordinates 2968408..2968776 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GR930_RS14545 2963686..2964756 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
GR930_RS14550 2964892..2965569 + 678 WP_001362823.1 hypothetical protein -
GR930_RS14555 2965585..2965995 + 411 WP_000846704.1 hypothetical protein -
GR930_RS14560 2965992..2966816 + 825 WP_163408008.1 DUF945 domain-containing protein -
GR930_RS14565 2967079..2967552 + 474 WP_001385393.1 antirestriction protein -
GR930_RS14570 2967568..2968044 + 477 WP_001186773.1 RadC family protein -
GR930_RS14575 2968107..2968328 + 222 WP_000692323.1 DUF987 domain-containing protein -
GR930_RS14580 2968408..2968776 + 369 WP_001546021.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
GR930_RS14585 2968865..2969239 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
GR930_RS14590 2969236..2969430 + 195 WP_000988601.1 hypothetical protein -
GR930_RS14595 2969443..2969556 + 114 WP_001161660.1 DUF957 domain-containing protein -
GR930_RS14600 2969919..2970665 - 747 Protein_2842 IS21-like element ISEc12 family helper ATPase IstB -
GR930_RS14605 2970680..2972181 - 1502 Protein_2843 IS21-like element ISEc12 family transposase -
GR930_RS14610 2972433..2972606 - 174 WP_032082634.1 transposase domain-containing protein -
GR930_RS14615 2972633..2972815 + 183 WP_001016348.1 hypothetical protein -
GR930_RS14620 2972916..2973245 - 330 WP_000450409.1 DUF496 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T35434 WP_000854814.1 NZ_AP022351:2968865-2969239 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T35434 NZ_AP022351:2968865-2969239 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTACTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13607.47 Da        Isoelectric Point: 6.3139

>AT35434 WP_001546021.1 NZ_AP022351:2968408-2968776 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGLFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT35434 NZ_AP022351:2968408-2968776 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCAGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A641DSP2

References