Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2234385..2235980 Replicon chromosome
Accession NZ_AP022347
Organism Fluviibacter phosphoraccumulans strain ICHIJ1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ICHIJ1_RS11115 Protein ID WP_162050649.1
Coordinates 2234385..2235716 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ICHIJ1_RS11120 Protein ID WP_162050650.1
Coordinates 2235720..2235980 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICHIJ1_RS11090 2229839..2230885 - 1047 WP_162050645.1 phosphate ABC transporter substrate-binding protein PstS -
ICHIJ1_RS11095 2230990..2232078 - 1089 WP_162050646.1 tRNA 2-selenouridine(34) synthase MnmH -
ICHIJ1_RS11100 2232078..2233112 - 1035 WP_162050647.1 selenide, water dikinase SelD -
ICHIJ1_RS11105 2233109..2233372 - 264 WP_202930741.1 hypothetical protein -
ICHIJ1_RS11110 2233369..2234184 - 816 WP_162050648.1 DUF4239 domain-containing protein -
ICHIJ1_RS11115 2234385..2235716 - 1332 WP_162050649.1 type II toxin-antitoxin system HipA family toxin Toxin
ICHIJ1_RS11120 2235720..2235980 - 261 WP_162050650.1 helix-turn-helix domain-containing protein Antitoxin
ICHIJ1_RS11130 2236505..2237899 + 1395 WP_162050651.1 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB -
ICHIJ1_RS11135 2237902..2238903 + 1002 WP_162050652.1 PhoH family protein -
ICHIJ1_RS11140 2238913..2239380 + 468 WP_162050653.1 rRNA maturation RNase YbeY -
ICHIJ1_RS11145 2239387..2240286 + 900 WP_162050654.1 CBS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-66)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49444.51 Da        Isoelectric Point: 7.0156

>T35408 WP_162050649.1 NZ_AP022347:c2235716-2234385 [Fluviibacter phosphoraccumulans]
MGRRSLSQKLTVWMNGIQVGVWEILRQGERFTYADAWISNAQGRPLSLSLPFVPGNAPYQGEEVGYYFDNLLPDSDAIRR
RLAQRYQANGTDAFQLLAKIGRDCVGALQFLPEGEMPTDVDQIQGRPLSEAEIAQHLRRVSTDTMLGQVELDDGLRLSIA
GAQEKTAFLRHKGQWLLPQGSTPTTHIFKLPLGLVGHMQADMRTSVENEWLCSKIMATYGVPIASCEIASFEDQKALVVA
RFDRKISTDGRWIVRLPQEDFCQAMGTSPLHKYQADGGPSITSSMNLLLGSENKDEDRRNFFKTQILFWLLAATDGHGKN
FSIAHLPGGAYRATPIYDVLSAHPVLGSGKNKIPYQKAKMAMAVRGSMNHYLIDKIQRRHWISQGQQVGLSAEMTEALIE
EVISQTDTVIDRVSQLLPVDFPLDIAEAIFEGMKKQRLKLAND

Download         Length: 1332 bp

>T35408 NZ_AP022347:c2235716-2234385 [Fluviibacter phosphoraccumulans]
ATGGGACGGCGTTCACTATCGCAAAAGCTGACGGTGTGGATGAATGGCATCCAGGTTGGCGTTTGGGAGATCTTGCGTCA
AGGTGAGCGCTTTACCTATGCGGATGCGTGGATTTCCAATGCGCAGGGACGCCCGCTGTCTTTGTCGCTCCCATTCGTGC
CGGGTAATGCGCCGTATCAAGGCGAGGAGGTTGGTTATTATTTTGACAACCTTTTGCCGGACAGCGATGCAATCCGTCGT
CGTTTGGCGCAGCGTTATCAGGCAAACGGAACAGATGCGTTTCAACTGCTGGCAAAGATTGGTCGTGATTGCGTTGGTGC
ACTTCAATTTTTGCCTGAGGGCGAGATGCCAACCGATGTTGATCAGATACAGGGCAGACCTCTAAGCGAAGCAGAGATTG
CGCAACATCTTCGACGCGTGTCGACTGATACGATGCTGGGGCAGGTTGAGCTTGACGATGGTCTGAGGCTGTCGATTGCT
GGTGCACAGGAAAAGACGGCCTTTTTGCGGCATAAGGGGCAATGGCTGCTACCGCAGGGCAGCACACCAACAACACATAT
CTTTAAGTTGCCACTGGGATTGGTAGGGCATATGCAGGCGGATATGCGCACCTCGGTTGAGAATGAGTGGCTGTGTTCAA
AAATTATGGCGACTTATGGTGTTCCGATTGCCTCATGTGAGATTGCATCTTTTGAAGATCAGAAGGCGCTGGTCGTAGCG
CGTTTTGACCGCAAAATATCAACAGACGGGCGATGGATCGTTCGTCTTCCTCAAGAAGATTTTTGCCAAGCCATGGGGAC
CTCGCCGCTACATAAGTATCAAGCCGATGGTGGGCCGAGTATTACTTCGTCTATGAACCTATTGCTGGGTTCCGAAAACA
AGGACGAAGATCGACGTAATTTTTTTAAGACGCAGATTCTATTCTGGCTATTGGCAGCCACTGATGGCCATGGAAAGAAT
TTCAGCATCGCGCATCTGCCGGGTGGGGCATATCGCGCCACCCCCATTTACGATGTGTTATCAGCGCACCCGGTATTAGG
ATCGGGTAAAAACAAGATTCCGTATCAGAAAGCCAAGATGGCGATGGCCGTGCGCGGCTCAATGAACCATTACCTGATTG
ATAAGATCCAGCGGCGTCATTGGATCTCTCAGGGGCAACAGGTTGGCCTAAGTGCTGAGATGACCGAAGCACTGATTGAA
GAAGTGATTAGTCAAACGGATACCGTGATTGATCGTGTCAGCCAGTTGCTGCCAGTAGATTTTCCGTTAGATATCGCCGA
AGCGATCTTCGAGGGAATGAAGAAGCAGCGTCTTAAGTTGGCGAACGATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9736.27 Da        Isoelectric Point: 9.6580

>AT35408 WP_162050650.1 NZ_AP022347:c2235980-2235720 [Fluviibacter phosphoraccumulans]
MIYPIKTLKQLPLFLKGFRKKKGLTQASMAEQLGISQQAYARFEANPETATLERLFLVLRTLDVEISLAHSDTKQADVAS
NTQEPW

Download         Length: 261 bp

>AT35408 NZ_AP022347:c2235980-2235720 [Fluviibacter phosphoraccumulans]
ATGATTTATCCCATAAAGACGCTCAAGCAACTCCCTTTGTTCCTAAAAGGATTCAGGAAAAAAAAGGGGCTGACCCAAGC
CTCGATGGCTGAACAGCTTGGCATCAGCCAGCAGGCTTACGCGCGCTTCGAAGCTAACCCGGAGACGGCGACCTTGGAAC
GGTTATTTCTGGTTTTGCGGACGCTGGATGTTGAGATTTCGTTGGCGCACTCAGATACCAAGCAAGCCGACGTAGCAAGC
AATACCCAAGAGCCTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References