Detailed information of TA system TA035398

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvT-higA/RES-HigA
• Location: 1081861..1082664
• Replicon: chromosome
• Accession: NZ_AP022347
• Organism: Fluviibacter phosphoraccumulans strain ICHIJ1

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: -
• Locus tag: ICHIJ1_RS05515
• Protein ID: WP_202930692.1
• Coordinates: 1081861..1082343 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ICHIJ1_RS05520
• Protein ID: WP_162049661.1
• Coordinates: 1082356..1082664 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICHIJ1_RS05495	1076919..1077971	+	1053	WP_162049656.1	ATP-binding protein	-
ICHIJ1_RS05500	1077949..1080480	+	2532	WP_162049657.1	S8 family peptidase	-
ICHIJ1_RS05505	1080487..1081347	+	861	WP_162049658.1	hypothetical protein	-
ICHIJ1_RS05510	1081418..1081825	+	408	WP_162049659.1	MbcA/ParS/Xre antitoxin family protein	-
ICHIJ1_RS05515	1081861..1082343	+	483	WP_202930692.1	RES family NAD+ phosphorylase	Toxin
ICHIJ1_RS05520	1082356..1082664	+	309	WP_162049661.1	HigA family addiction module antidote protein	Antitoxin
ICHIJ1_RS05525	1082807..1082998	+	192	WP_162049662.1	hypothetical protein	-
ICHIJ1_RS05530	1082970..1083362	+	393	WP_162049663.1	hypothetical protein	-
ICHIJ1_RS05535	1083442..1085400	+	1959	WP_162049664.1	ATP-binding protein	-
ICHIJ1_RS05540	1085451..1086692	+	1242	WP_162049665.1	hypothetical protein	-
ICHIJ1_RS05545	1086739..1087086	+	348	WP_162049666.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ICHIJ1_RS05550	1087104..1087421	+	318	WP_202930781.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	gmd / fcl	1058849..1102748	43899

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-135)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-84)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17073.12 Da
• Isoelectric Point: 4.4067

>T35398 WP_202930692.1 NZ_AP022347:1081861-1082343 [Fluviibacter phosphoraccumulans]
MHAPKWAVAPTSGAGAGKHGGRANRPGIDAIYLALETQTAINEYQQTSTLLPPGTLTSYKLSAAPVVDFTGGYSASVWEP
IWEDFYCDWRELWFNQGVEPPSWIAADLALAAGAKGILFSSRLAAGGTNLVLFNSSLVAPDFLDVYDPGNALPQNQASWS

Nucleotide

• Length: 483 bp

>T35398 NZ_AP022347:1081861-1082343 [Fluviibacter phosphoraccumulans]
ATGCACGCTCCCAAGTGGGCTGTTGCACCTACCAGCGGTGCTGGAGCTGGTAAACATGGTGGCCGTGCCAATCGGCCAGG
TATTGATGCCATTTATTTGGCGCTAGAGACTCAGACGGCTATTAATGAGTACCAACAGACTTCAACTTTGTTGCCACCCG
GCACGTTAACCAGTTACAAATTGTCTGCCGCGCCCGTTGTAGATTTTACCGGCGGGTACAGCGCCTCGGTATGGGAGCCA
ATTTGGGAAGACTTCTACTGCGACTGGCGCGAGCTCTGGTTTAATCAGGGGGTCGAGCCTCCTAGCTGGATTGCAGCAGA
TTTGGCTTTAGCTGCGGGTGCAAAGGGGATTCTCTTTTCTTCGCGGTTAGCTGCTGGCGGAACGAATCTCGTGCTGTTTA
ATAGCTCGCTGGTCGCTCCTGATTTCTTAGACGTTTATGATCCGGGTAATGCTTTGCCACAGAACCAGGCGTCATGGTCT
TGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11573.31 Da
• Isoelectric Point: 6.2289

>AT35398 WP_162049661.1 NZ_AP022347:1082356-1082664 [Fluviibacter phosphoraccumulans]
MIKNGMRPIHSGEILREEFLEPLEMSANALSLELHVPAPRINDIVREKRAVSTDTAMRLARYFGTTAQFWLNLQTAFDLK
QAEAEVGAQIMREVHQREPVAA

Nucleotide

• Length: 309 bp

>AT35398 NZ_AP022347:1082356-1082664 [Fluviibacter phosphoraccumulans]
ATGATCAAAAACGGAATGCGCCCCATCCACTCGGGCGAGATTTTGCGGGAAGAGTTTCTGGAGCCGCTGGAAATGTCGGC
AAATGCCTTGTCGCTAGAGCTACATGTGCCAGCACCACGTATTAACGACATTGTGCGTGAAAAGCGTGCTGTTTCAACAG
ATACCGCAATGCGCCTGGCCCGTTACTTCGGAACCACGGCACAGTTTTGGCTTAACCTACAGACGGCATTTGACCTAAAA
CAGGCTGAGGCAGAGGTTGGCGCTCAGATTATGCGGGAAGTGCATCAGCGGGAGCCGGTTGCTGCTTGA