Detailed information of TA system TA035396

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 384822..385308
• Replicon: chromosome
• Accession: NZ_AP022347
• Organism: Fluviibacter phosphoraccumulans strain ICHIJ1

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: ICHIJ1_RS02015
• Protein ID: WP_162049066.1
• Coordinates: 385033..385308 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: ICHIJ1_RS02010
• Protein ID: WP_162049065.1
• Coordinates: 384822..385049 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICHIJ1_RS01985	380976..382397	+	1422	WP_202930720.1	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	-
ICHIJ1_RS01990	382406..383263	+	858	WP_162049061.1	hypothetical protein	-
ICHIJ1_RS01995	383305..384054	-	750	WP_162049062.1	YdcF family protein	-
ICHIJ1_RS02000	384149..384406	+	258	WP_162049063.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
ICHIJ1_RS02005	384403..384681	+	279	WP_162049064.1	plasmid stabilization protein	-
ICHIJ1_RS02010	384822..385049	+	228	WP_162049065.1	ribbon-helix-helix protein, CopG family	Antitoxin
ICHIJ1_RS02015	385033..385308	+	276	WP_162049066.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ICHIJ1_RS02020	385325..385813	-	489	WP_162049067.1	hypothetical protein	-
ICHIJ1_RS02025	385947..386693	+	747	WP_162049068.1	autoinducer binding domain-containing protein	-
ICHIJ1_RS02030	386662..386922	-	261	WP_202930798.1	helix-turn-helix domain-containing protein	-
ICHIJ1_RS02035	387116..388264	+	1149	WP_162049069.1	Fic family protein	-
ICHIJ1_RS02040	388319..389701	-	1383	WP_162049070.1	Fic family protein	-
ICHIJ1_RS02045	389938..390228	+	291	WP_162049071.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-35)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10601.41 Da
• Isoelectric Point: 10.2349

>T35396 WP_162049066.1 NZ_AP022347:385033-385308 [Fluviibacter phosphoraccumulans]
MPWIIKYTESAQRQLKKLDKAAALRVLDYMDERIGILADPRSAGKNLVGPRMGSYWRYRVGDLRVICDIQDQTVVILVIE
IGHRREVYRGR

Nucleotide

• Length: 276 bp

>T35396 NZ_AP022347:385033-385308 [Fluviibacter phosphoraccumulans]
TTGCCATGGATCATTAAATATACCGAGTCTGCGCAGCGGCAGCTTAAGAAGCTGGACAAGGCGGCTGCGCTGCGGGTCCT
CGATTATATGGATGAGCGGATCGGTATTCTGGCTGACCCGAGAAGCGCAGGTAAAAATCTAGTTGGGCCACGGATGGGTT
CATATTGGCGGTATCGGGTTGGGGATCTGCGGGTGATCTGCGATATTCAGGATCAAACCGTTGTTATTCTGGTCATTGAG
ATCGGCCATCGGCGAGAGGTGTATCGGGGGCGGTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8464.55 Da
• Isoelectric Point: 4.5084

>AT35396 WP_162049065.1 NZ_AP022347:384822-385049 [Fluviibacter phosphoraccumulans]
MAVSLRLDPEIEQRLDHLAAQTGRAKSYYLRELIEGGLDDLEGFYLADATMERVRKGEESVLDAAEVRKSIAMDH

Nucleotide

• Length: 228 bp

>AT35396 NZ_AP022347:384822-385049 [Fluviibacter phosphoraccumulans]
ATGGCGGTGTCGCTCAGGCTGGACCCTGAAATTGAACAACGGCTCGATCATTTGGCGGCCCAGACCGGGCGTGCCAAGTC
TTACTATTTACGCGAGCTGATCGAGGGTGGCCTCGATGATCTAGAAGGTTTTTACCTGGCGGATGCCACGATGGAGCGTG
TTCGCAAAGGTGAGGAGTCTGTGCTGGATGCGGCTGAAGTAAGGAAGTCGATTGCCATGGATCATTAA