Detailed information of TA system TA035394

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 345446..345977
• Replicon: chromosome
• Accession: NZ_AP022347
• Organism: Fluviibacter phosphoraccumulans strain ICHIJ1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ICHIJ1_RS01825
• Protein ID: WP_162049029.1
• Coordinates: 345696..345977 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: ICHIJ1_RS01820
• Protein ID: WP_162049028.1
• Coordinates: 345446..345709 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICHIJ1_RS01790	341774..342712	-	939	WP_162049023.1	tyrosine-type recombinase/integrase	-
ICHIJ1_RS01795	342933..343238	+	306	WP_162049024.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ICHIJ1_RS01800	343231..343548	+	318	WP_162049025.1	putative addiction module antidote protein	-
ICHIJ1_RS01805	343722..344258	+	537	WP_162049026.1	hypothetical protein	-
ICHIJ1_RS01810	344328..344513	+	186	WP_162049027.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
ICHIJ1_RS12165	344692..344949	+	258	WP_202930725.1	hypothetical protein	-
ICHIJ1_RS12170	345010..345342	+	333	WP_202930724.1	AAA family ATPase	-
ICHIJ1_RS01820	345446..345709	+	264	WP_162049028.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ICHIJ1_RS01825	345696..345977	+	282	WP_162049029.1	type II toxin-antitoxin system YafQ family toxin	Toxin
ICHIJ1_RS01830	346288..347133	+	846	WP_162049030.1	NYN domain-containing protein	-
ICHIJ1_RS01835	347519..348688	+	1170	WP_162049031.1	nucleotide sugar dehydrogenase	-
ICHIJ1_RS01840	348700..349677	+	978	WP_162049032.1	SDR family oxidoreductase	-
ICHIJ1_RS01845	349696..350694	+	999	WP_162049033.1	UDP-N-acetylglucosamine 4,6-dehydratase (inverting)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	332167..347133	14966

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-78)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10827.49 Da
• Isoelectric Point: 8.0689

>T35394 WP_162049029.1 NZ_AP022347:345696-345977 [Fluviibacter phosphoraccumulans]
MRAIERTGQFKRDYKRESKGIYRSVLDAELVPVLIALASDMPLAERYRDHALTGEWKDHRDCHVKPDLLLIYRKPDDQLL
QLVRLGSHSELGI

Nucleotide

• Length: 282 bp

>T35394 NZ_AP022347:345696-345977 [Fluviibacter phosphoraccumulans]
ATGCGGGCAATTGAGCGTACCGGTCAGTTTAAGCGAGACTACAAGCGAGAGTCTAAAGGCATCTATAGATCTGTACTAGA
TGCGGAATTGGTGCCGGTTTTAATCGCGCTAGCCTCAGATATGCCATTGGCAGAGCGCTACAGAGATCATGCGCTCACTG
GTGAATGGAAAGATCATCGTGATTGCCATGTGAAACCCGATCTGTTGTTGATCTATCGCAAGCCGGATGATCAGCTCCTC
CAGCTCGTACGCTTGGGCTCGCACAGCGAGTTAGGTATTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9527.08 Da
• Isoelectric Point: 7.2038

>AT35394 WP_162049028.1 NZ_AP022347:345446-345709 [Fluviibacter phosphoraccumulans]
MAANAVVRARIDEHIKEEASTVLAAMGLTVSDAFRIMLTRVAYEKALPFEPLVPNETTVKAMRDARKAKLARFDSVEALM
ADLHAGN

Nucleotide

• Length: 264 bp

>AT35394 NZ_AP022347:345446-345709 [Fluviibacter phosphoraccumulans]
ATGGCTGCAAACGCTGTCGTTCGGGCGCGCATTGACGAACACATCAAAGAAGAGGCTTCGACCGTTCTCGCGGCGATGGG
GTTAACGGTGTCTGATGCCTTCCGGATTATGTTGACTCGTGTCGCCTATGAAAAGGCGCTGCCTTTTGAGCCTCTGGTGC
CCAATGAAACAACGGTTAAAGCCATGCGGGATGCTCGTAAAGCCAAGCTGGCGCGCTTTGATAGTGTCGAAGCGTTAATG
GCTGACCTGCATGCGGGCAATTGA