Detailed information of TA system TA035390

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvT-higA/RES-HigA
• Location: 1970875..1971678
• Replicon: chromosome
• Accession: NZ_AP022345
• Organism: Fluviibacter phosphoraccumulans strain ICHIAU1

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: -
• Locus tag: ICHIAU1_RS09815
• Protein ID: WP_202930692.1
• Coordinates: 1971196..1971678 (-)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ICHIAU1_RS09810
• Protein ID: WP_162049661.1
• Coordinates: 1970875..1971183 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICHIAU1_RS09780	1966118..1966435	-	318	WP_202930781.1	XRE family transcriptional regulator	-
ICHIAU1_RS09785	1966453..1966800	-	348	WP_162049666.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ICHIAU1_RS09790	1966847..1968088	-	1242	WP_162049665.1	hypothetical protein	-
ICHIAU1_RS09795	1968139..1970097	-	1959	WP_162049664.1	ATP-binding protein	-
ICHIAU1_RS09800	1970177..1970569	-	393	WP_162049663.1	hypothetical protein	-
ICHIAU1_RS09805	1970541..1970732	-	192	WP_162049662.1	hypothetical protein	-
ICHIAU1_RS09810	1970875..1971183	-	309	WP_162049661.1	HigA family addiction module antidote protein	Antitoxin
ICHIAU1_RS09815	1971196..1971678	-	483	WP_202930692.1	RES family NAD+ phosphorylase	Toxin
ICHIAU1_RS09820	1971714..1972121	-	408	WP_162049659.1	MbcA/ParS/Xre antitoxin family protein	-
ICHIAU1_RS09825	1972192..1973052	-	861	WP_162049658.1	hypothetical protein	-
ICHIAU1_RS09830	1973059..1975590	-	2532	WP_162049657.1	S8 family peptidase	-
ICHIAU1_RS09835	1975568..1976620	-	1053	WP_162049656.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fcl / gmd	1951104..1994441	43337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-135)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-84)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17073.12 Da
• Isoelectric Point: 4.4067

>T35390 WP_202930692.1 NZ_AP022345:c1971678-1971196 [Fluviibacter phosphoraccumulans]
MHAPKWAVAPTSGAGAGKHGGRANRPGIDAIYLALETQTAINEYQQTSTLLPPGTLTSYKLSAAPVVDFTGGYSASVWEP
IWEDFYCDWRELWFNQGVEPPSWIAADLALAAGAKGILFSSRLAAGGTNLVLFNSSLVAPDFLDVYDPGNALPQNQASWS

Nucleotide

• Length: 483 bp

>T35390 NZ_AP022345:c1971678-1971196 [Fluviibacter phosphoraccumulans]
ATGCACGCTCCCAAGTGGGCTGTTGCACCTACCAGCGGTGCTGGAGCTGGTAAACATGGTGGCCGTGCCAATCGGCCAGG
TATTGATGCCATTTATTTGGCGCTAGAGACTCAGACGGCTATTAATGAGTACCAACAGACTTCAACTTTGTTGCCACCCG
GCACGTTAACCAGTTACAAATTGTCTGCCGCGCCCGTTGTAGATTTTACCGGCGGGTACAGCGCCTCGGTATGGGAGCCA
ATTTGGGAAGACTTCTACTGCGACTGGCGCGAGCTCTGGTTTAATCAGGGGGTCGAGCCTCCTAGCTGGATTGCAGCAGA
TTTGGCTTTAGCTGCGGGTGCAAAGGGGATTCTCTTTTCTTCGCGGTTAGCTGCTGGCGGAACGAATCTCGTGCTGTTTA
ATAGCTCGCTGGTCGCTCCTGATTTCTTAGACGTTTATGATCCGGGTAATGCTTTGCCACAGAACCAGGCGTCATGGTCT
TGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11573.31 Da
• Isoelectric Point: 6.2289

>AT35390 WP_162049661.1 NZ_AP022345:c1971183-1970875 [Fluviibacter phosphoraccumulans]
MIKNGMRPIHSGEILREEFLEPLEMSANALSLELHVPAPRINDIVREKRAVSTDTAMRLARYFGTTAQFWLNLQTAFDLK
QAEAEVGAQIMREVHQREPVAA

Nucleotide

• Length: 309 bp

>AT35390 NZ_AP022345:c1971183-1970875 [Fluviibacter phosphoraccumulans]
ATGATCAAAAACGGAATGCGCCCCATCCACTCGGGCGAGATTTTGCGGGAAGAGTTTCTGGAGCCGCTGGAAATGTCGGC
AAATGCCTTGTCGCTAGAGCTACATGTGCCAGCACCACGTATTAACGACATTGTGCGTGAAAAGCGTGCTGTTTCAACAG
ATACCGCAATGCGCCTGGCCCGTTACTTCGGAACCACGGCACAGTTTTGGCTTAACCTACAGACGGCATTTGACCTAAAA
CAGGCTGAGGCAGAGGTTGGCGCTCAGATTATGCGGGAAGTGCATCAGCGGGAGCCGGTTGCTGCTTGA