Detailed information of TA system TA035388

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1956594..1957138
• Replicon: chromosome
• Accession: NZ_AP022345
• Organism: Fluviibacter phosphoraccumulans strain ICHIAU1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ICHIAU1_RS09700
• Protein ID: WP_162049681.1
• Coordinates: 1956594..1956872 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ICHIAU1_RS09705
• Protein ID: WP_162049680.1
• Coordinates: 1956872..1957138 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICHIAU1_RS09680	1952527..1954362	-	1836	WP_162049685.1	hypothetical protein	-
ICHIAU1_RS09685	1954413..1955192	-	780	WP_162049684.1	sulfite exporter TauE/SafE family protein	-
ICHIAU1_RS09690	1955185..1955985	-	801	WP_162049683.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-
ICHIAU1_RS09695	1955988..1956587	-	600	WP_162049682.1	adenylyl-sulfate kinase	-
ICHIAU1_RS09700	1956594..1956872	-	279	WP_162049681.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ICHIAU1_RS09705	1956872..1957138	-	267	WP_162049680.1	ribbon-helix-helix protein, CopG family	Antitoxin
ICHIAU1_RS09710	1957205..1958509	-	1305	WP_202930690.1	glycosyltransferase family 4 protein	-
ICHIAU1_RS09715	1958524..1959471	-	948	WP_202930691.1	hypothetical protein	-
ICHIAU1_RS09720	1959490..1959960	-	471	WP_162049679.1	hypothetical protein	-
ICHIAU1_RS09725	1960029..1960295	-	267	WP_162049678.1	Txe/YoeB family addiction module toxin	-
ICHIAU1_RS09730	1960295..1960555	-	261	WP_162049677.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
ICHIAU1_RS09735	1960781..1961440	-	660	WP_162049676.1	transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fcl / gmd	1951104..1994441	43337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10707.55 Da
• Isoelectric Point: 10.7462

>T35388 WP_162049681.1 NZ_AP022345:c1956872-1956594 [Fluviibacter phosphoraccumulans]
MVKVAWTRHAVQDLGRLHEFLKVVNPTAAAKILQNLVKAPSALIGNPRMGERIEAFESREIRRLLVARYELRYEIKDATL
YILRIGHTREER

Nucleotide

• Length: 279 bp

>T35388 NZ_AP022345:c1956872-1956594 [Fluviibacter phosphoraccumulans]
ATGGTTAAGGTTGCATGGACGCGCCACGCGGTTCAGGATTTGGGTCGGCTCCATGAGTTTCTCAAAGTCGTCAACCCGAC
AGCGGCAGCTAAGATCCTACAGAATCTGGTGAAAGCACCGAGTGCACTGATCGGAAATCCTCGGATGGGGGAGCGAATAG
AAGCCTTTGAGTCACGCGAAATTCGCCGCTTGTTGGTCGCTCGATACGAATTGCGATATGAAATTAAGGATGCCACGCTT
TATATTTTGCGGATCGGGCATACACGAGAAGAACGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9960.16 Da
• Isoelectric Point: 4.1649

>AT35388 WP_162049680.1 NZ_AP022345:c1957138-1956872 [Fluviibacter phosphoraccumulans]
MANLETKVLTAHVPIDLADKVDYLAERLDRSRGWVVKQALAAWVDQEEERTRLTEEAMADVDQENLVAHESMLAWADSLD
TETPRALP

Nucleotide

• Length: 267 bp

>AT35388 NZ_AP022345:c1957138-1956872 [Fluviibacter phosphoraccumulans]
ATGGCAAACCTAGAAACCAAAGTCCTGACTGCGCACGTTCCGATCGATCTTGCTGATAAGGTGGATTATCTGGCGGAACG
ATTGGATCGCTCCCGCGGTTGGGTAGTTAAACAGGCGCTCGCGGCGTGGGTTGATCAGGAAGAAGAGCGAACCCGTCTGA
CCGAAGAGGCCATGGCTGATGTTGACCAAGAAAATCTGGTAGCCCATGAGAGTATGCTGGCATGGGCAGATAGCCTTGAT
ACAGAAACCCCACGGGCACTCCCTTAA