Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1400233..1400848 Replicon chromosome
Accession NZ_AP022345
Organism Fluviibacter phosphoraccumulans strain ICHIAU1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ICHIAU1_RS07000 Protein ID WP_162050169.1
Coordinates 1400233..1400538 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ICHIAU1_RS07005 Protein ID WP_162050168.1
Coordinates 1400531..1400848 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICHIAU1_RS06980 1396243..1396803 - 561 WP_162050173.1 hypothetical protein -
ICHIAU1_RS06985 1396814..1398142 - 1329 WP_162050172.1 TolC family protein -
ICHIAU1_RS06990 1398217..1398591 - 375 WP_162050171.1 hypothetical protein -
ICHIAU1_RS06995 1398650..1399879 - 1230 WP_162050170.1 IS256 family transposase -
ICHIAU1_RS07000 1400233..1400538 + 306 WP_162050169.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ICHIAU1_RS07005 1400531..1400848 + 318 WP_162050168.1 putative addiction module antidote protein Antitoxin
ICHIAU1_RS07010 1400914..1401753 - 840 WP_162050167.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
ICHIAU1_RS07015 1401750..1402352 - 603 WP_162050166.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
ICHIAU1_RS07020 1402442..1403464 - 1023 WP_162050165.1 hypothetical protein -
ICHIAU1_RS07025 1403918..1404061 + 144 WP_162071257.1 hypothetical protein -
ICHIAU1_RS07030 1404158..1405372 + 1215 WP_162071258.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1327901..1403740 75839
- flank IS/Tn - - 1398650..1399879 1229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-85)

Antitoxin

Cro/C1-type helix-turn-helix domain

(51-94)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11471.35 Da        Isoelectric Point: 9.9485

>T35383 WP_162050169.1 NZ_AP022345:1400233-1400538 [Fluviibacter phosphoraccumulans]
MYTVIQIPAFSDWLRAIKDRQTQVRLMKRLRKAQLGNLGDVKQVGSGVWEMREFFGPGWRMYYVQRGDLLIVMLGGGDKS
TQTADIAKAISLASLVEIEHD

Download         Length: 306 bp

>T35383 NZ_AP022345:1400233-1400538 [Fluviibacter phosphoraccumulans]
ATGTACACCGTTATACAAATCCCGGCCTTTTCTGATTGGCTCCGAGCCATTAAAGATCGCCAGACACAGGTTCGTCTAAT
GAAGCGCCTTCGTAAAGCGCAATTAGGTAATCTGGGGGATGTTAAACAGGTGGGCAGTGGTGTTTGGGAGATGCGGGAGT
TTTTCGGCCCCGGCTGGCGCATGTACTACGTTCAGCGTGGGGATTTGTTGATCGTGATGCTGGGTGGTGGAGATAAATCT
ACTCAAACAGCAGACATTGCTAAAGCCATTTCTCTTGCGAGCCTGGTGGAGATTGAACATGACTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11516.30 Da        Isoelectric Point: 5.1568

>AT35383 WP_162050168.1 NZ_AP022345:1400531-1400848 [Fluviibacter phosphoraccumulans]
MTKKIKLADCRPFDIAEYLDDETMITEYMNVVLEENDPAMLASALGDIARARGMSQLAKETGLSRESLYKGLSGDRIPST
ETLLKVIHALGFKLSVSKVDTVAHA

Download         Length: 318 bp

>AT35383 NZ_AP022345:1400531-1400848 [Fluviibacter phosphoraccumulans]
ATGACTAAGAAGATTAAACTTGCCGATTGCCGACCATTTGATATTGCAGAATATCTGGACGACGAAACCATGATTACAGA
GTATATGAACGTTGTGCTTGAAGAGAACGACCCAGCGATGTTGGCTTCAGCCTTGGGCGATATCGCTCGTGCTCGTGGCA
TGTCACAACTTGCGAAAGAGACTGGCCTCAGCAGAGAAAGCTTATACAAGGGGTTGTCTGGTGACCGTATCCCAAGTACC
GAGACCCTGCTAAAAGTCATTCATGCGCTGGGATTCAAGCTATCAGTATCCAAGGTGGATACAGTCGCGCACGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References