Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 1260243..1260798 Replicon chromosome
Accession NZ_AP022345
Organism Fluviibacter phosphoraccumulans strain ICHIAU1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ICHIAU1_RS06270 Protein ID WP_162050318.1
Coordinates 1260243..1260578 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ICHIAU1_RS06275 Protein ID WP_162050317.1
Coordinates 1260568..1260798 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICHIAU1_RS06235 1255486..1256208 - 723 WP_162050324.1 UDP-2,3-diacylglucosamine diphosphatase -
ICHIAU1_RS06240 1256205..1256702 - 498 WP_162050323.1 peptidylprolyl isomerase -
ICHIAU1_RS06245 1256835..1258226 + 1392 WP_162050322.1 cysteine--tRNA ligase -
ICHIAU1_RS06250 1258261..1259427 + 1167 WP_162050966.1 MFS transporter -
ICHIAU1_RS06255 1259593..1259826 + 234 WP_162050321.1 CopG family transcriptional regulator -
ICHIAU1_RS06260 1259813..1260070 + 258 WP_162050320.1 type II toxin-antitoxin system RelE/ParE family toxin -
ICHIAU1_RS06265 1260076..1260231 + 156 WP_162050319.1 hypothetical protein -
ICHIAU1_RS06270 1260243..1260578 - 336 WP_162050318.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ICHIAU1_RS06275 1260568..1260798 - 231 WP_162050317.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ICHIAU1_RS06280 1260882..1261118 + 237 WP_162050316.1 hypothetical protein -
ICHIAU1_RS06285 1261244..1261723 + 480 WP_162050315.1 hypothetical protein -
ICHIAU1_RS06290 1261729..1262058 + 330 WP_162050314.1 hypothetical protein -
ICHIAU1_RS06295 1262389..1262940 + 552 WP_162050313.1 hypothetical protein -
ICHIAU1_RS06300 1263054..1264199 - 1146 WP_162050312.1 molecular chaperone DnaJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-102)

Antitoxin

SpoVT-AbrB domain

(6-47)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12292.22 Da        Isoelectric Point: 10.7556

>T35382 WP_162050318.1 NZ_AP022345:c1260578-1260243 [Fluviibacter phosphoraccumulans]
VGFEQFDVVRVPFPFTDRTATKNRPALVLSQSVFSNAADHSVLVMVTSAMNDWPLDCPIKDLQAAGLPAPSRIRFKLFTL
DNRLIRGKIGALSAADRQAFKKQFDRLVATS

Download         Length: 336 bp

>T35382 NZ_AP022345:c1260578-1260243 [Fluviibacter phosphoraccumulans]
GTGGGCTTTGAACAATTCGACGTGGTCAGAGTGCCCTTCCCGTTCACGGATCGTACTGCTACTAAAAACAGACCTGCACT
GGTTCTCTCTCAATCCGTCTTTAGTAATGCAGCAGACCATTCAGTGCTTGTGATGGTCACCTCGGCGATGAATGATTGGC
CTTTGGACTGCCCCATAAAAGACCTGCAAGCCGCAGGTTTGCCAGCACCCTCAAGAATCCGCTTCAAACTCTTCACGCTC
GACAACAGACTGATACGAGGAAAGATTGGTGCACTTTCCGCCGCTGATAGACAAGCATTCAAAAAGCAATTTGATCGATT
GGTCGCAACAAGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8480.50 Da        Isoelectric Point: 4.1954

>AT35382 WP_162050317.1 NZ_AP022345:c1260798-1260568 [Fluviibacter phosphoraccumulans]
MPAIAKITSKGQTTIPAEVRESLNFNPGDLLEWEVNADGSARVRRIQPLDLEYMRAVEGTLTEWGCAEDEEAYRGL

Download         Length: 231 bp

>AT35382 NZ_AP022345:c1260798-1260568 [Fluviibacter phosphoraccumulans]
ATGCCAGCTATCGCCAAAATCACCTCAAAAGGCCAAACTACCATTCCAGCAGAGGTCAGAGAGTCGCTTAACTTTAATCC
GGGCGATTTGCTGGAATGGGAAGTGAATGCAGACGGTTCAGCCAGAGTGCGGCGTATTCAACCACTAGACCTAGAGTACA
TGCGCGCCGTTGAAGGCACGCTCACCGAATGGGGCTGCGCGGAAGACGAAGAGGCGTATCGTGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References