Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 851975..853570 Replicon chromosome
Accession NZ_AP022345
Organism Fluviibacter phosphoraccumulans strain ICHIAU1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ICHIAU1_RS04330 Protein ID WP_162050649.1
Coordinates 852239..853570 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ICHIAU1_RS04325 Protein ID WP_162050650.1
Coordinates 851975..852235 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICHIAU1_RS04300 847669..848568 - 900 WP_162050654.1 CBS domain-containing protein -
ICHIAU1_RS04305 848575..849042 - 468 WP_162050653.1 rRNA maturation RNase YbeY -
ICHIAU1_RS04310 849052..850053 - 1002 WP_162050652.1 PhoH family protein -
ICHIAU1_RS04315 850056..851450 - 1395 WP_162050651.1 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB -
ICHIAU1_RS04325 851975..852235 + 261 WP_162050650.1 helix-turn-helix domain-containing protein Antitoxin
ICHIAU1_RS04330 852239..853570 + 1332 WP_162050649.1 type II toxin-antitoxin system HipA family toxin Toxin
ICHIAU1_RS04335 853771..854586 + 816 WP_162050648.1 DUF4239 domain-containing protein -
ICHIAU1_RS04340 854583..854846 + 264 WP_202930741.1 hypothetical protein -
ICHIAU1_RS04345 854843..855877 + 1035 WP_162050647.1 selenide, water dikinase SelD -
ICHIAU1_RS04350 855877..856965 + 1089 WP_162050646.1 tRNA 2-selenouridine(34) synthase MnmH -
ICHIAU1_RS04355 857070..858116 + 1047 WP_162050645.1 phosphate ABC transporter substrate-binding protein PstS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-66)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49444.51 Da        Isoelectric Point: 7.0156

>T35380 WP_162050649.1 NZ_AP022345:852239-853570 [Fluviibacter phosphoraccumulans]
MGRRSLSQKLTVWMNGIQVGVWEILRQGERFTYADAWISNAQGRPLSLSLPFVPGNAPYQGEEVGYYFDNLLPDSDAIRR
RLAQRYQANGTDAFQLLAKIGRDCVGALQFLPEGEMPTDVDQIQGRPLSEAEIAQHLRRVSTDTMLGQVELDDGLRLSIA
GAQEKTAFLRHKGQWLLPQGSTPTTHIFKLPLGLVGHMQADMRTSVENEWLCSKIMATYGVPIASCEIASFEDQKALVVA
RFDRKISTDGRWIVRLPQEDFCQAMGTSPLHKYQADGGPSITSSMNLLLGSENKDEDRRNFFKTQILFWLLAATDGHGKN
FSIAHLPGGAYRATPIYDVLSAHPVLGSGKNKIPYQKAKMAMAVRGSMNHYLIDKIQRRHWISQGQQVGLSAEMTEALIE
EVISQTDTVIDRVSQLLPVDFPLDIAEAIFEGMKKQRLKLAND

Download         Length: 1332 bp

>T35380 NZ_AP022345:852239-853570 [Fluviibacter phosphoraccumulans]
ATGGGACGGCGTTCACTATCGCAAAAGCTGACGGTGTGGATGAATGGCATCCAGGTTGGCGTTTGGGAGATCTTGCGTCA
AGGTGAGCGCTTTACCTATGCGGATGCGTGGATTTCCAATGCGCAGGGACGCCCGCTGTCTTTGTCGCTCCCATTCGTGC
CGGGTAATGCGCCGTATCAAGGCGAGGAGGTTGGTTATTATTTTGACAACCTTTTGCCGGACAGCGATGCAATCCGTCGT
CGTTTGGCGCAGCGTTATCAGGCAAACGGAACAGATGCGTTTCAACTGCTGGCAAAGATTGGTCGTGATTGCGTTGGTGC
ACTTCAATTTTTGCCTGAGGGCGAGATGCCAACCGATGTTGATCAGATACAGGGCAGACCTCTAAGCGAAGCAGAGATTG
CGCAACATCTTCGACGCGTGTCGACTGATACGATGCTGGGGCAGGTTGAGCTTGACGATGGTCTGAGGCTGTCGATTGCT
GGTGCACAGGAAAAGACGGCCTTTTTGCGGCATAAGGGGCAATGGCTGCTACCGCAGGGCAGCACACCAACAACACATAT
CTTTAAGTTGCCACTGGGATTGGTAGGGCATATGCAGGCGGATATGCGCACCTCGGTTGAGAATGAGTGGCTGTGTTCAA
AAATTATGGCGACTTATGGTGTTCCGATTGCCTCATGTGAGATTGCATCTTTTGAAGATCAGAAGGCGCTGGTCGTAGCG
CGTTTTGACCGCAAAATATCAACAGACGGGCGATGGATCGTTCGTCTTCCTCAAGAAGATTTTTGCCAAGCCATGGGGAC
CTCGCCGCTACATAAGTATCAAGCCGATGGTGGGCCGAGTATTACTTCGTCTATGAACCTATTGCTGGGTTCCGAAAACA
AGGACGAAGATCGACGTAATTTTTTTAAGACGCAGATTCTATTCTGGCTATTGGCAGCCACTGATGGCCATGGAAAGAAT
TTCAGCATCGCGCATCTGCCGGGTGGGGCATATCGCGCCACCCCCATTTACGATGTGTTATCAGCGCACCCGGTATTAGG
ATCGGGTAAAAACAAGATTCCGTATCAGAAAGCCAAGATGGCGATGGCCGTGCGCGGCTCAATGAACCATTACCTGATTG
ATAAGATCCAGCGGCGTCATTGGATCTCTCAGGGGCAACAGGTTGGCCTAAGTGCTGAGATGACCGAAGCACTGATTGAA
GAAGTGATTAGTCAAACGGATACCGTGATTGATCGTGTCAGCCAGTTGCTGCCAGTAGATTTTCCGTTAGATATCGCCGA
AGCGATCTTCGAGGGAATGAAGAAGCAGCGTCTTAAGTTGGCGAACGATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9736.27 Da        Isoelectric Point: 9.6580

>AT35380 WP_162050650.1 NZ_AP022345:851975-852235 [Fluviibacter phosphoraccumulans]
MIYPIKTLKQLPLFLKGFRKKKGLTQASMAEQLGISQQAYARFEANPETATLERLFLVLRTLDVEISLAHSDTKQADVAS
NTQEPW

Download         Length: 261 bp

>AT35380 NZ_AP022345:851975-852235 [Fluviibacter phosphoraccumulans]
ATGATTTATCCCATAAAGACGCTCAAGCAACTCCCTTTGTTCCTAAAAGGATTCAGGAAAAAAAAGGGGCTGACCCAAGC
CTCGATGGCTGAACAGCTTGGCATCAGCCAGCAGGCTTACGCGCGCTTCGAAGCTAACCCGGAGACGGCGACCTTGGAAC
GGTTATTTCTGGTTTTGCGGACGCTGGATGTTGAGATTTCGTTGGCGCACTCAGATACCAAGCAAGCCGACGTAGCAAGC
AATACCCAAGAGCCTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References