Detailed information of TA system TA035378

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 312829..313444
• Replicon: chromosome
• Accession: NZ_AP022345
• Organism: Fluviibacter phosphoraccumulans strain ICHIAU1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ICHIAU1_RS01585
• Protein ID: WP_162049024.1
• Coordinates: 313139..313444 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ICHIAU1_RS01580
• Protein ID: WP_162049025.1
• Coordinates: 312829..313146 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICHIAU1_RS01550	309244..310089	-	846	WP_162049030.1	NYN domain-containing protein	-
ICHIAU1_RS01555	310400..310681	-	282	WP_162049029.1	type II toxin-antitoxin system YafQ family toxin	-
ICHIAU1_RS01560	310668..310931	-	264	WP_162049028.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
ICHIAU1_RS11990	311035..311367	-	333	WP_202930724.1	AAA family ATPase	-
ICHIAU1_RS11995	311428..311685	-	258	WP_202930725.1	hypothetical protein	-
ICHIAU1_RS01570	311864..312049	-	186	WP_162049027.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
ICHIAU1_RS01575	312119..312676	-	558	WP_162071196.1	hypothetical protein	-
ICHIAU1_RS01580	312829..313146	-	318	WP_162049025.1	putative addiction module antidote protein	Antitoxin
ICHIAU1_RS01585	313139..313444	-	306	WP_162049024.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ICHIAU1_RS01590	313665..314603	+	939	WP_162049023.1	tyrosine-type recombinase/integrase	-
ICHIAU1_RS01595	314707..316266	-	1560	WP_202930726.1	Fic family protein	-
ICHIAU1_RS01600	316621..317658	-	1038	WP_162049022.1	UDP-glucose 4-epimerase GalE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ugd	306701..324210	17509

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (8-96)

Antitoxin

• Cro/C1-type helix-turn-helix domain (50-91)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11468.41 Da
• Isoelectric Point: 9.9485

>T35378 WP_162049024.1 NZ_AP022345:c313444-313139 [Fluviibacter phosphoraccumulans]
MYTVIPIPAFSDWLRAIKDRPTQVRLMKRLRKAQLGNLGDVKQVGSGVWEMREFFGPGWRMYYIQRGDLLIVMLGGGDKS
TQSADIAKAISLANLMEIEHD

Nucleotide

• Length: 306 bp

>T35378 NZ_AP022345:c313444-313139 [Fluviibacter phosphoraccumulans]
ATGTATACCGTTATACCAATCCCGGCCTTTTCTGACTGGCTCCGAGCCATTAAAGATCGCCCGACACAGGTTCGTCTGAT
GAAGCGCCTTCGTAAAGCGCAATTAGGCAATCTTGGGGATGTTAAACAGGTGGGCAGTGGTGTTTGGGAGATGCGGGAGT
TTTTCGGCCCCGGCTGGCGTATGTATTACATTCAGCGTGGGGATCTGTTGATCGTGATGCTGGGTGGTGGTGATAAATCC
ACGCAGTCAGCGGATATCGCCAAAGCAATTTCTCTAGCGAACCTAATGGAGATTGAACATGACTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11476.19 Da
• Isoelectric Point: 5.1568

>AT35378 WP_162049025.1 NZ_AP022345:c313146-312829 [Fluviibacter phosphoraccumulans]
MTKKIKLSDCRPFDIAEYLDDEAMITEYMNSVLEENDPAMLASALGDIARARGMTQLAKETGLSRESLYKGLSGDRIPST
ETLLKVIHALGFKLSVSKADTVAHA

Nucleotide

• Length: 318 bp

>AT35378 NZ_AP022345:c313146-312829 [Fluviibacter phosphoraccumulans]
ATGACTAAGAAGATTAAGCTTTCCGACTGCCGTCCATTTGATATTGCAGAATATCTGGACGATGAAGCCATGATTACCGA
GTACATGAACTCGGTCCTGGAAGAGAACGACCCAGCGATGCTGGCTTCAGCATTAGGCGATATCGCCCGTGCTCGTGGCA
TGACCCAATTGGCGAAGGAAACAGGCCTCAGCAGGGAAAGCCTATATAAGGGTTTATCGGGTGACCGTATCCCAAGCACT
GAAACGCTGCTGAAGGTAATTCACGCACTGGGATTCAAGTTGTCGGTATCTAAAGCGGATACAGTCGCACACGCTTGA