Detailed information of TA system TA035377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 310400..310931
• Replicon: chromosome
• Accession: NZ_AP022345
• Organism: Fluviibacter phosphoraccumulans strain ICHIAU1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ICHIAU1_RS01555
• Protein ID: WP_162049029.1
• Coordinates: 310400..310681 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: ICHIAU1_RS01560
• Protein ID: WP_162049028.1
• Coordinates: 310668..310931 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICHIAU1_RS01535	305684..306682	-	999	WP_162049033.1	UDP-N-acetylglucosamine 4,6-dehydratase (inverting)	-
ICHIAU1_RS01540	306701..307678	-	978	WP_162049032.1	SDR family oxidoreductase	-
ICHIAU1_RS01545	307690..308859	-	1170	WP_162049031.1	nucleotide sugar dehydrogenase	-
ICHIAU1_RS01550	309244..310089	-	846	WP_162049030.1	NYN domain-containing protein	-
ICHIAU1_RS01555	310400..310681	-	282	WP_162049029.1	type II toxin-antitoxin system YafQ family toxin	Toxin
ICHIAU1_RS01560	310668..310931	-	264	WP_162049028.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ICHIAU1_RS11990	311035..311367	-	333	WP_202930724.1	AAA family ATPase	-
ICHIAU1_RS11995	311428..311685	-	258	WP_202930725.1	hypothetical protein	-
ICHIAU1_RS01570	311864..312049	-	186	WP_162049027.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
ICHIAU1_RS01575	312119..312676	-	558	WP_162071196.1	hypothetical protein	-
ICHIAU1_RS01580	312829..313146	-	318	WP_162049025.1	putative addiction module antidote protein	-
ICHIAU1_RS01585	313139..313444	-	306	WP_162049024.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ICHIAU1_RS01590	313665..314603	+	939	WP_162049023.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ugd	306701..324210	17509

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-78)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10827.49 Da
• Isoelectric Point: 8.0689

>T35377 WP_162049029.1 NZ_AP022345:c310681-310400 [Fluviibacter phosphoraccumulans]
MRAIERTGQFKRDYKRESKGIYRSVLDAELVPVLIALASDMPLAERYRDHALTGEWKDHRDCHVKPDLLLIYRKPDDQLL
QLVRLGSHSELGI

Nucleotide

• Length: 282 bp

>T35377 NZ_AP022345:c310681-310400 [Fluviibacter phosphoraccumulans]
ATGCGGGCAATTGAGCGTACCGGTCAGTTTAAGCGAGACTACAAGCGAGAGTCTAAAGGCATCTATAGATCTGTACTAGA
TGCGGAATTGGTGCCGGTTTTAATCGCGCTAGCCTCAGATATGCCATTGGCAGAGCGCTACAGAGATCATGCGCTCACTG
GTGAATGGAAAGATCATCGTGATTGCCATGTGAAACCCGATCTGTTGTTGATCTATCGCAAGCCGGATGATCAGCTCCTC
CAGCTCGTACGCTTGGGCTCGCACAGCGAGTTAGGTATTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9527.08 Da
• Isoelectric Point: 7.2038

>AT35377 WP_162049028.1 NZ_AP022345:c310931-310668 [Fluviibacter phosphoraccumulans]
MAANAVVRARIDEHIKEEASTVLAAMGLTVSDAFRIMLTRVAYEKALPFEPLVPNETTVKAMRDARKAKLARFDSVEALM
ADLHAGN

Nucleotide

• Length: 264 bp

>AT35377 NZ_AP022345:c310931-310668 [Fluviibacter phosphoraccumulans]
ATGGCTGCAAACGCTGTCGTTCGGGCGCGCATTGACGAACACATCAAAGAAGAGGCTTCGACCGTTCTCGCGGCGATGGG
GTTAACGGTGTCTGATGCCTTCCGGATTATGTTGACTCGTGTCGCCTATGAAAAGGCGCTGCCTTTTGAGCCTCTGGTGC
CCAATGAAACAACGGTTAAAGCCATGCGGGATGCTCGTAAAGCCAAGCTGGCGCGCTTTGATAGTGTCGAAGCGTTAATG
GCTGACCTGCATGCGGGCAATTGA