Detailed information of TA system TA035375

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 271071..271557
• Replicon: chromosome
• Accession: NZ_AP022345
• Organism: Fluviibacter phosphoraccumulans strain ICHIAU1

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: ICHIAU1_RS01365
• Protein ID: WP_162049066.1
• Coordinates: 271071..271346 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: ICHIAU1_RS01370
• Protein ID: WP_162049065.1
• Coordinates: 271330..271557 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICHIAU1_RS01335	266151..266441	-	291	WP_162049071.1	co-chaperone GroES	-
ICHIAU1_RS01340	266678..268060	+	1383	WP_162049070.1	Fic family protein	-
ICHIAU1_RS01345	268115..269263	-	1149	WP_162049069.1	Fic family protein	-
ICHIAU1_RS01350	269415..269717	+	303	WP_202930719.1	helix-turn-helix domain-containing protein	-
ICHIAU1_RS01355	269686..270432	-	747	WP_162049068.1	autoinducer binding domain-containing protein	-
ICHIAU1_RS01360	270566..271054	+	489	WP_162049067.1	hypothetical protein	-
ICHIAU1_RS01365	271071..271346	-	276	WP_162049066.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ICHIAU1_RS01370	271330..271557	-	228	WP_162049065.1	ribbon-helix-helix protein, CopG family	Antitoxin
ICHIAU1_RS01375	271698..271976	-	279	WP_162049064.1	plasmid stabilization protein	-
ICHIAU1_RS01380	271973..272230	-	258	WP_162049063.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
ICHIAU1_RS01385	272325..273074	+	750	WP_162049062.1	YdcF family protein	-
ICHIAU1_RS01390	273116..273973	-	858	WP_162049061.1	hypothetical protein	-
ICHIAU1_RS01395	273982..275403	-	1422	WP_202930720.1	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-35)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10601.41 Da
• Isoelectric Point: 10.2349

>T35375 WP_162049066.1 NZ_AP022345:c271346-271071 [Fluviibacter phosphoraccumulans]
MPWIIKYTESAQRQLKKLDKAAALRVLDYMDERIGILADPRSAGKNLVGPRMGSYWRYRVGDLRVICDIQDQTVVILVIE
IGHRREVYRGR

Nucleotide

• Length: 276 bp

>T35375 NZ_AP022345:c271346-271071 [Fluviibacter phosphoraccumulans]
TTGCCATGGATCATTAAATATACCGAGTCTGCGCAGCGGCAGCTTAAGAAGCTGGACAAGGCGGCTGCGCTGCGGGTCCT
CGATTATATGGATGAGCGGATCGGTATTCTGGCTGACCCGAGAAGCGCAGGTAAAAATCTAGTTGGGCCACGGATGGGTT
CATATTGGCGGTATCGGGTTGGGGATCTGCGGGTGATCTGCGATATTCAGGATCAAACCGTTGTTATTCTGGTCATTGAG
ATCGGCCATCGGCGAGAGGTGTATCGGGGGCGGTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8464.55 Da
• Isoelectric Point: 4.5084

>AT35375 WP_162049065.1 NZ_AP022345:c271557-271330 [Fluviibacter phosphoraccumulans]
MAVSLRLDPEIEQRLDHLAAQTGRAKSYYLRELIEGGLDDLEGFYLADATMERVRKGEESVLDAAEVRKSIAMDH

Nucleotide

• Length: 228 bp

>AT35375 NZ_AP022345:c271557-271330 [Fluviibacter phosphoraccumulans]
ATGGCGGTGTCGCTCAGGCTGGACCCTGAAATTGAACAACGGCTCGATCATTTGGCGGCCCAGACCGGGCGTGCCAAGTC
TTACTATTTACGCGAGCTGATCGAGGGTGGCCTCGATGATCTAGAAGGTTTTTACCTGGCGGATGCCACGATGGAGCGTG
TTCGCAAAGGTGAGGAGTCTGTGCTGGATGCGGCTGAAGTAAGGAAGTCGATTGCCATGGATCATTAA