Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 151027..151700 Replicon plasmid pMSC49a
Accession NZ_AP022333
Organism Methylosinus sp. C49 isolate Methylosinus sp. C49

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GYH34_RS19085 Protein ID WP_161915196.1
Coordinates 151278..151700 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GYH34_RS19080 Protein ID WP_161915195.1
Coordinates 151027..151281 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYH34_RS19055 146607..148055 + 1449 WP_161915191.1 HAMP domain-containing histidine kinase -
GYH34_RS19060 148135..148566 - 432 WP_161915192.1 DoxX family protein -
GYH34_RS19065 148613..149311 - 699 WP_161915193.1 pirin family protein -
GYH34_RS19070 149947..150279 + 333 WP_161915194.1 hypothetical protein -
GYH34_RS19075 150665..150787 - 123 Protein_124 DJ-1/PfpI family protein -
GYH34_RS19080 151027..151281 + 255 WP_161915195.1 plasmid stabilization protein Antitoxin
GYH34_RS19085 151278..151700 + 423 WP_161915196.1 type II toxin-antitoxin system VapC family toxin Toxin
GYH34_RS19090 152286..153440 - 1155 WP_161915197.1 SRPBCC domain-containing protein -
GYH34_RS19095 153437..155065 - 1629 Protein_128 MFS transporter -
GYH34_RS19100 155192..155539 - 348 WP_161915198.1 metalloregulator ArsR/SmtB family transcription factor -
GYH34_RS19105 156193..156618 + 426 WP_161915199.1 putative toxin-antitoxin system toxin component, PIN family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..324889 324889


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14874.08 Da        Isoelectric Point: 5.8928

>T35367 WP_161915196.1 NZ_AP022333:151278-151700 [Methylosinus sp. C49]
MILLDTNVVSEAMKPEPDPAVRRWLDEQAAETLYLSSVTIAELMFGVGALPKGKRKDRLTAALEGVLELFADRILPFETN
AARRYSDLAVKARAAGKGFPTPDGYIAAIAASHGFVVASRDRSAFAAAGLSVIDPWAAGA

Download         Length: 423 bp

>T35367 NZ_AP022333:151278-151700 [Methylosinus sp. C49]
ATGATCCTGCTCGACACCAATGTCGTCTCCGAGGCGATGAAGCCCGAACCGGACCCGGCGGTCCGCCGATGGCTCGATGA
GCAGGCGGCGGAAACGCTCTATCTCTCGAGCGTCACGATCGCTGAGCTGATGTTCGGCGTCGGCGCGCTTCCCAAGGGCA
AGCGCAAGGACAGGTTGACCGCCGCGCTCGAAGGCGTGCTGGAGCTGTTCGCGGACCGCATCCTCCCGTTCGAGACGAAC
GCGGCGCGCCGCTATTCCGATCTGGCGGTGAAGGCGCGCGCTGCCGGAAAGGGGTTCCCCACACCGGATGGCTATATCGC
CGCCATTGCCGCATCGCATGGTTTCGTCGTTGCATCCCGCGACCGCAGCGCATTCGCGGCCGCCGGCCTGAGCGTGATCG
ACCCCTGGGCCGCCGGGGCCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9399.68 Da        Isoelectric Point: 8.9326

>AT35367 WP_161915195.1 NZ_AP022333:151027-151281 [Methylosinus sp. C49]
MPAVTIRNLSEETHRALKVRAAQHGRSTEAEIRDILENAVRPANRLRLGSALAEMSRKIGLTNADVEALEQAREQKPAEP
LRFE

Download         Length: 255 bp

>AT35367 NZ_AP022333:151027-151281 [Methylosinus sp. C49]
ATGCCTGCTGTCACCATCCGCAACCTCTCCGAAGAGACGCATCGCGCGCTGAAGGTCCGTGCGGCGCAGCACGGACGCAG
CACGGAAGCGGAGATACGCGACATCCTGGAGAACGCTGTGCGCCCGGCCAATCGTCTCCGCCTTGGAAGCGCGCTGGCGG
AAATGAGCCGGAAGATCGGCCTGACCAACGCCGACGTCGAAGCCCTCGAACAGGCCCGCGAGCAGAAGCCGGCAGAACCG
CTGCGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References