Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1869055..1869722 Replicon chromosome
Accession NZ_AP022332
Organism Methylosinus sp. C49 isolate Methylosinus sp. C49

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GYH34_RS09030 Protein ID WP_161913291.1
Coordinates 1869055..1869474 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GYH34_RS09035 Protein ID WP_108917441.1
Coordinates 1869471..1869722 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYH34_RS09015 1864540..1865091 - 552 WP_161913288.1 Uma2 family endonuclease -
GYH34_RS09020 1865098..1865721 - 624 WP_161913289.1 DUF938 domain-containing protein -
GYH34_RS09025 1865860..1869000 + 3141 WP_161913290.1 autotransporter domain-containing protein -
GYH34_RS09030 1869055..1869474 - 420 WP_161913291.1 type II toxin-antitoxin system VapC family toxin Toxin
GYH34_RS09035 1869471..1869722 - 252 WP_108917441.1 toxin-antitoxin system Antitoxin
GYH34_RS09040 1869788..1871248 - 1461 WP_161914954.1 amidophosphoribosyltransferase -
GYH34_RS09045 1871333..1872016 - 684 WP_018266270.1 CvpA family protein -
GYH34_RS09050 1872330..1872605 - 276 WP_024880626.1 hypothetical protein -
GYH34_RS09055 1872984..1874402 - 1419 WP_161913292.1 DNA repair protein RadA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15518.81 Da        Isoelectric Point: 8.9608

>T35366 WP_161913291.1 NZ_AP022332:c1869474-1869055 [Methylosinus sp. C49]
MILLDTNVVSELVKARPHPLVLAWLDRHPFSSVWISTISVMELRFGLELLDPSRRKAELAAALARLTESTFGDRIAPFDL
KAAEAAGRLAAARRRNGTTVDHRDTQIAGIALAHRARLVTRNLRDFADLDVEVTNPWNE

Download         Length: 420 bp

>T35366 NZ_AP022332:c1869474-1869055 [Methylosinus sp. C49]
TTGATTCTGCTCGACACGAATGTCGTCTCGGAACTCGTGAAAGCGAGACCGCATCCATTGGTCCTGGCGTGGCTCGATCG
CCATCCTTTCTCTTCGGTCTGGATATCAACTATTTCCGTGATGGAGCTGCGCTTTGGCTTGGAGCTTCTCGACCCGAGCC
GCAGGAAGGCGGAACTCGCCGCTGCGCTCGCCCGGCTGACGGAATCGACATTCGGCGACCGCATAGCGCCTTTCGACTTG
AAGGCCGCCGAGGCGGCCGGCCGGCTCGCGGCCGCACGCCGCCGCAATGGAACGACCGTCGACCACCGCGACACACAGAT
CGCCGGCATTGCTCTCGCCCATCGCGCGCGGCTCGTGACACGCAATCTGCGCGATTTCGCCGATCTCGATGTCGAGGTGA
CGAATCCTTGGAATGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9333.27 Da        Isoelectric Point: 4.5593

>AT35366 WP_108917441.1 NZ_AP022332:c1869722-1869471 [Methylosinus sp. C49]
MAQLLVRNLADDVKQKLRRRASEHGRSMEEEARRIIEAAVGGQGAEDYGWASRLSAQFSEFGFSDDEASVFELREAARPA
EFD

Download         Length: 252 bp

>AT35366 NZ_AP022332:c1869722-1869471 [Methylosinus sp. C49]
ATGGCTCAGCTGCTCGTACGCAATCTCGCCGACGACGTGAAGCAAAAGCTTCGGCGCCGAGCGTCGGAGCATGGGCGCAG
CATGGAGGAAGAGGCGCGCCGCATCATAGAGGCGGCAGTCGGCGGCCAAGGGGCCGAAGACTATGGATGGGCCTCTCGCC
TCTCTGCGCAATTCTCCGAATTCGGCTTCTCCGATGACGAGGCGAGCGTTTTTGAGCTCCGCGAAGCGGCGCGGCCGGCC
GAATTCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References