Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 248099..248627 Replicon chromosome
Accession NZ_AP022332
Organism Methylosinus sp. C49 isolate Methylosinus sp. C49

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GYH34_RS01170 Protein ID WP_161911995.1
Coordinates 248099..248380 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag GYH34_RS01175 Protein ID WP_161911996.1
Coordinates 248367..248627 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYH34_RS01145 243468..244175 + 708 WP_161911991.1 rhomboid family intramembrane serine protease -
GYH34_RS01150 244187..244960 + 774 WP_161911992.1 hypothetical protein -
GYH34_RS01155 245231..245977 + 747 WP_161911993.1 electron transfer flavoprotein subunit beta/FixA family protein -
GYH34_RS01160 245978..246922 + 945 WP_161911994.1 FAD-binding protein -
GYH34_RS01165 247172..248053 + 882 WP_018267072.1 3-hydroxybutyryl-CoA dehydrogenase -
GYH34_RS01170 248099..248380 - 282 WP_161911995.1 type II toxin-antitoxin system YafQ family toxin Toxin
GYH34_RS01175 248367..248627 - 261 WP_161911996.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GYH34_RS01180 248679..249308 - 630 WP_161911997.1 protein-methionine-sulfoxide reductase heme-binding subunit MsrQ -
GYH34_RS01185 249310..250245 - 936 WP_161911998.1 protein-methionine-sulfoxide reductase catalytic subunit MsrP -
GYH34_RS01190 250346..251236 - 891 WP_161911999.1 RNA polymerase sigma factor RpoH -
GYH34_RS01195 251568..251798 + 231 WP_161912000.1 NAD(P)H-dependent oxidoreductase -
GYH34_RS01200 251785..252105 + 321 WP_161912001.1 type II toxin-antitoxin system PemK/MazF family toxin -
GYH34_RS01205 252113..252556 - 444 WP_161912002.1 DUF2267 domain-containing protein -
GYH34_RS01210 252581..253612 - 1032 WP_161912003.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-77)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10980.64 Da        Isoelectric Point: 8.5096

>T35363 WP_161911995.1 NZ_AP022332:c248380-248099 [Methylosinus sp. C49]
MRAIKYTSRFRHDYRRERSGVLGKKIDQLLLDAVNLLAADQPLPARYCDHELIGEWKDHRDCHLRPDLLLIYRKPDAERL
ELVRLGSHSELGF

Download         Length: 282 bp

>T35363 NZ_AP022332:c248380-248099 [Methylosinus sp. C49]
ATGCGGGCGATTAAATACACCTCGCGCTTCCGGCACGATTATCGGCGTGAACGGTCAGGGGTGCTGGGCAAGAAAATCGA
TCAGCTGCTTTTGGACGCCGTCAACCTTCTGGCGGCAGATCAGCCGTTGCCAGCGCGATATTGCGACCATGAATTGATCG
GGGAATGGAAGGATCACAGAGATTGCCACCTTCGCCCCGACCTATTGCTCATATACCGCAAGCCTGACGCTGAAAGGCTG
GAATTGGTGCGCCTCGGCTCACACAGCGAGCTCGGATTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9276.71 Da        Isoelectric Point: 4.5680

>AT35363 WP_161911996.1 NZ_AP022332:c248627-248367 [Methylosinus sp. C49]
MTNTVVRARIDEHVKEEAAAVLATIGLTVSDAFRLMMVRIATDKTLPFELLVPNAETVEAMKAARRGELVDVGAPENLLQ
SLNAGD

Download         Length: 261 bp

>AT35363 NZ_AP022332:c248627-248367 [Methylosinus sp. C49]
ATGACCAACACCGTCGTCCGTGCGCGCATCGACGAGCATGTGAAAGAGGAAGCCGCCGCCGTGCTGGCGACCATCGGCCT
GACTGTGTCCGATGCGTTCCGGCTCATGATGGTTCGGATCGCGACGGACAAGACCTTGCCGTTCGAGCTGCTCGTGCCGA
ACGCTGAAACGGTCGAGGCTATGAAGGCCGCTCGCCGTGGTGAGCTCGTCGATGTCGGCGCCCCTGAAAACCTGCTCCAG
AGCCTGAATGCGGGCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References