Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 190141..190715 Replicon chromosome
Accession NZ_AP022332
Organism Methylosinus sp. C49 isolate Methylosinus sp. C49

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GYH34_RS00885 Protein ID WP_161911947.1
Coordinates 190141..190473 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GYH34_RS00890 Protein ID WP_161911948.1
Coordinates 190473..190715 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYH34_RS00865 185529..187364 + 1836 WP_161911944.1 membrane protein insertase YidC -
GYH34_RS00870 187372..188034 + 663 WP_161911945.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
GYH34_RS00875 188093..188977 + 885 WP_142862633.1 acetylglutamate kinase -
GYH34_RS00880 189071..189796 + 726 WP_161911946.1 pyrimidine 5'-nucleotidase -
GYH34_RS00885 190141..190473 - 333 WP_161911947.1 endoribonuclease MazF Toxin
GYH34_RS00890 190473..190715 - 243 WP_161911948.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GYH34_RS00895 190916..191290 + 375 WP_161911949.1 hypothetical protein -
GYH34_RS00900 191349..193652 + 2304 WP_161911950.1 TonB-dependent siderophore receptor -
GYH34_RS00905 193665..195212 + 1548 WP_161911951.1 PepSY domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-105)

Antitoxin

Antitoxin PemI-like

(1-79)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11747.72 Da        Isoelectric Point: 10.2592

>T35362 WP_161911947.1 NZ_AP022332:c190473-190141 [Methylosinus sp. C49]
MAAYTPERGDIVWLSFDPQAGHEQAGHRPALVLSPNAYNAKTGLMICCPMTTKIKGYPFEVAIAGPTPSAALVDQVKSLD
WRARKAKKKGSASKSELAVATAKLRPLLGI

Download         Length: 333 bp

>T35362 NZ_AP022332:c190473-190141 [Methylosinus sp. C49]
ATGGCGGCCTATACGCCCGAGCGTGGCGACATAGTATGGCTGAGCTTCGATCCACAGGCCGGCCATGAGCAAGCGGGGCA
TCGTCCCGCGCTCGTGTTGAGCCCGAATGCCTATAACGCCAAGACCGGGCTGATGATCTGCTGTCCGATGACGACGAAGA
TCAAGGGCTATCCCTTCGAGGTCGCGATCGCGGGACCGACGCCATCGGCGGCCCTCGTCGATCAGGTGAAAAGTCTGGAC
TGGCGCGCGCGCAAGGCGAAGAAGAAGGGCTCCGCCTCGAAGAGCGAGCTGGCGGTGGCAACGGCGAAGCTCAGGCCGCT
ATTGGGAATTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8627.79 Da        Isoelectric Point: 4.2213

>AT35362 WP_161911948.1 NZ_AP022332:c190715-190473 [Methylosinus sp. C49]
MRAIVKKWGNSAAVRIPSAVMEQARLEIDQAVEVRVEGGSVVIEPLAAPEFSLEDLLAGVTSENLHEEESFGPPVGRETL

Download         Length: 243 bp

>AT35362 NZ_AP022332:c190715-190473 [Methylosinus sp. C49]
ATGCGAGCGATCGTCAAAAAATGGGGCAACTCCGCGGCTGTGCGCATACCCTCGGCCGTCATGGAGCAGGCGCGCCTCGA
GATCGACCAAGCCGTCGAGGTGCGCGTCGAAGGCGGCAGCGTGGTGATAGAGCCGCTCGCGGCGCCCGAATTCTCTCTCG
AGGACCTTCTCGCAGGTGTGACGTCTGAAAACCTGCATGAGGAGGAGAGCTTCGGACCGCCTGTCGGCCGCGAGACGCTC
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References