Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 190141..190715 Replicon chromosome
Accession NZ_AP022332
Organism Methylosinus sp. C49 isolate Methylosinus sp. C49

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GYH34_RS00885 Protein ID WP_161911947.1
Coordinates 190141..190473 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GYH34_RS00890 Protein ID WP_161911948.1
Coordinates 190473..190715 (-) Length 81 a.a.

Genomic Context

GYH34_RS00865GYH34_RS00870GYH34_RS00875GYH34_RS00880GYH34_RS00895GYH34_RS00900GYH34_RS00905GYH34_RS00885GYH34_RS00890
Location: 185529..187364 (1836 bp)
Type: Others
Protein ID: WP_161911944.1
Location: 187372..188034 (663 bp)
Type: Others
Protein ID: WP_161911945.1
Location: 188093..188977 (885 bp)
Type: Others
Protein ID: WP_142862633.1
Location: 189071..189796 (726 bp)
Type: Others
Protein ID: WP_161911946.1
Location: 190916..191290 (375 bp)
Type: Others
Protein ID: WP_161911949.1
Location: 191349..193652 (2304 bp)
Type: Others
Protein ID: WP_161911950.1
Location: 193665..195212 (1548 bp)
Type: Others
Protein ID: WP_161911951.1
Location: 190141..190473 (333 bp)
Type: Toxin
Protein ID: WP_161911947.1
Location: 190473..190715 (243 bp)
Type: Antitoxin
Protein ID: WP_161911948.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GYH34_RS00865185529..187364+1836WP_161911944.1membrane protein insertase YidC-
GYH34_RS00870187372..188034+663WP_161911945.1ribosome biogenesis GTP-binding protein YihA/YsxC-
GYH34_RS00875188093..188977+885WP_142862633.1acetylglutamate kinase-
GYH34_RS00880189071..189796+726WP_161911946.1pyrimidine 5'-nucleotidase-
GYH34_RS00885190141..190473-333WP_161911947.1endoribonuclease MazFToxin
GYH34_RS00890190473..190715-243WP_161911948.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
GYH34_RS00895190916..191290+375WP_161911949.1hypothetical protein-
GYH34_RS00900191349..193652+2304WP_161911950.1TonB-dependent siderophore receptor-
GYH34_RS00905193665..195212+1548WP_161911951.1PepSY domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-105)

Antitoxin

Antitoxin PemI-like

(1-79)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11747.72 Da        Isoelectric Point: 10.2592

>T35362 WP_161911947.1 NZ_AP022332:c190473-190141 [Methylosinus sp. C49]
MAAYTPERGDIVWLSFDPQAGHEQAGHRPALVLSPNAYNAKTGLMICCPMTTKIKGYPFEVAIAGPTPSAALVDQVKSLD
WRARKAKKKGSASKSELAVATAKLRPLLGI

Download         Length: 333 bp

>T35362 NZ_AP022332:c190473-190141 [Methylosinus sp. C49]
ATGGCGGCCTATACGCCCGAGCGTGGCGACATAGTATGGCTGAGCTTCGATCCACAGGCCGGCCATGAGCAAGCGGGGCA
TCGTCCCGCGCTCGTGTTGAGCCCGAATGCCTATAACGCCAAGACCGGGCTGATGATCTGCTGTCCGATGACGACGAAGA
TCAAGGGCTATCCCTTCGAGGTCGCGATCGCGGGACCGACGCCATCGGCGGCCCTCGTCGATCAGGTGAAAAGTCTGGAC
TGGCGCGCGCGCAAGGCGAAGAAGAAGGGCTCCGCCTCGAAGAGCGAGCTGGCGGTGGCAACGGCGAAGCTCAGGCCGCT
ATTGGGAATTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8627.79 Da        Isoelectric Point: 4.2213

>AT35362 WP_161911948.1 NZ_AP022332:c190715-190473 [Methylosinus sp. C49]
MRAIVKKWGNSAAVRIPSAVMEQARLEIDQAVEVRVEGGSVVIEPLAAPEFSLEDLLAGVTSENLHEEESFGPPVGRETL

Download         Length: 243 bp

>AT35362 NZ_AP022332:c190715-190473 [Methylosinus sp. C49]
ATGCGAGCGATCGTCAAAAAATGGGGCAACTCCGCGGCTGTGCGCATACCCTCGGCCGTCATGGAGCAGGCGCGCCTCGA
GATCGACCAAGCCGTCGAGGTGCGCGTCGAAGGCGGCAGCGTGGTGATAGAGCCGCTCGCGGCGCCCGAATTCTCTCTCG
AGGACCTTCTCGCAGGTGTGACGTCTGAAAACCTGCATGAGGAGGAGAGCTTCGGACCGCCTGTCGGCCGCGAGACGCTC
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References