Detailed information of TA system TA035319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 423041..423518
• Replicon: chromosome
• Accession: NZ_AP022322
• Organism: Veillonella sp. S12025-13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KJS32_RS01855
• Protein ID: WP_024064148.1
• Coordinates: 423252..423518 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E4LDZ1
• Locus tag: KJS32_RS01850
• Protein ID: WP_009352129.1
• Coordinates: 423041..423262 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJS32_RS01830 (VEIS1202513_03660)	419281..420171	+	891	WP_024064152.1	phosphate ABC transporter substrate-binding protein	-
KJS32_RS01835 (VEIS1202513_03670)	420214..421110	+	897	WP_213467685.1	phosphate ABC transporter permease subunit PstC	-
KJS32_RS01840 (VEIS1202513_03680)	421097..421915	+	819	WP_213467686.1	ABC transporter permease subunit	-
KJS32_RS01845 (VEIS1202513_03690)	421915..422658	+	744	WP_213467687.1	ATP-binding cassette domain-containing protein	-
KJS32_RS01850 (VEIS1202513_03700)	423041..423262	+	222	WP_009352129.1	DUF6290 family protein	Antitoxin
KJS32_RS01855 (VEIS1202513_03710)	423252..423518	+	267	WP_024064148.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KJS32_RS01860 (VEIS1202513_03720)	423529..423741	+	213	WP_024064147.1	hypothetical protein	-
KJS32_RS01865 (VEIS1202513_03730)	423808..424893	+	1086	WP_024064146.1	hypothetical protein	-
KJS32_RS01870 (VEIS1202513_03740)	424987..425778	-	792	WP_213467688.1	carbon-nitrogen family hydrolase	-
KJS32_RS01875 (VEIS1202513_03750)	426019..426822	+	804	WP_213467689.1	polysaccharide deacetylase family protein	-
KJS32_RS01880 (VEIS1202513_03760)	426834..427772	+	939	WP_213467690.1	phosphodiester glycosidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10595.25 Da
• Isoelectric Point: 10.2849

>T35319 WP_024064148.1 NZ_AP022322:423252-423518 [Veillonella sp. S12025-13]
MAYKLEFSKRFDKQFSKLDKSMQRYLFNWLIKNIDNVENPRYSGKSLTGNKTGLWRYRIGNYRVIADINDDRCIILALEV
GHRKEIYK

Nucleotide

• Length: 267 bp

>T35319 NZ_AP022322:423252-423518 [Veillonella sp. S12025-13]
ATGGCTTATAAACTTGAATTTTCTAAAAGGTTTGACAAGCAATTTTCTAAATTAGATAAATCAATGCAACGCTATCTTTT
TAATTGGCTCATAAAAAATATAGATAATGTAGAAAACCCTAGGTACTCAGGCAAATCATTGACGGGGAATAAAACAGGGC
TGTGGCGTTATCGCATTGGTAATTATAGAGTCATAGCTGATATTAATGATGATAGATGTATTATTTTAGCGTTAGAAGTG
GGTCATCGAAAAGAAATTTACAAATAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8500.65 Da
• Isoelectric Point: 4.1835

>AT35319 WP_009352129.1 NZ_AP022322:423041-423262 [Veillonella sp. S12025-13]
MANISVRLNEQEEELFKTYAEFMDETLSTLFKKALLEKIEDEFDLKVGQKALAEYEQDPVTYSVAEMRAKYGL

Nucleotide

• Length: 222 bp

>AT35319 NZ_AP022322:423041-423262 [Veillonella sp. S12025-13]
ATGGCAAATATTTCAGTCCGTTTAAATGAACAAGAAGAAGAGTTATTTAAAACCTATGCTGAGTTTATGGATGAAACACT
TTCTACCCTCTTTAAGAAGGCTTTACTAGAAAAGATTGAAGACGAATTTGATCTTAAGGTAGGTCAAAAAGCATTAGCAG
AATACGAGCAAGATCCAGTTACCTATTCTGTAGCGGAAATGCGTGCAAAATATGGCTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A2S7YYS4