Detailed information of TA system TA035318

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2089222..2089859
• Replicon: chromosome
• Accession: NZ_AP022321
• Organism: Veillonella nakazawae strain T1-7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: VEIT17_RS09750
• Protein ID: WP_178885953.1
• Coordinates: 2089449..2089859 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: VEIT17_RS09745
• Protein ID: WP_178885951.1
• Coordinates: 2089222..2089452 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VEIT17_RS09730	2086057..2086914	+	858	WP_082717874.1	methylenetetrahydrofolate reductase	-
VEIT17_RS09735	2087088..2087552	-	465	WP_038125930.1	IS200/IS605 family transposase	-
VEIT17_RS09740	2087790..2088542	-	753	WP_178885949.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
VEIT17_RS09745	2089222..2089452	+	231	WP_178885951.1	antitoxin	Antitoxin
VEIT17_RS09750	2089449..2089859	+	411	WP_178885953.1	type II toxin-antitoxin system VapC family toxin	Toxin
VEIT17_RS09755	2089943..2091814	-	1872	WP_178885955.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG	-
VEIT17_RS09760	2092193..2093578	-	1386	WP_178885957.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
VEIT17_RS09765	2093766..2094563	-	798	WP_178885959.1	protein jag	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2087088..2087552	464

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (9-44)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15305.77 Da
• Isoelectric Point: 7.3820

>T35318 WP_178885953.1 NZ_AP022321:2089449-2089859 [Veillonella nakazawae]
MKYMLDTNICIYAIKQEPEVVLQKILKHHPSDICISSITYAELMHGVEKSQSKDKNRLALTLLLSPIQIVDFDSHAAEEY
GKIKADLQSQGKVIGPMDLLIASHAKSKGLTIVTNNTKEFKRVNQLEVEDWSKPLS

Nucleotide

• Length: 411 bp

>T35318 NZ_AP022321:2089449-2089859 [Veillonella nakazawae]
ATGAAGTATATGTTAGATACTAATATATGTATTTATGCTATCAAACAAGAGCCAGAAGTTGTACTACAAAAAATTTTAAA
GCATCATCCTTCAGATATCTGTATATCATCAATTACATATGCTGAGTTAATGCATGGTGTAGAAAAAAGTCAATCAAAAG
ATAAAAATAGATTAGCTTTAACACTTTTATTATCACCTATCCAAATTGTTGATTTTGACAGCCACGCTGCTGAGGAATAT
GGAAAAATAAAAGCCGATTTACAATCACAAGGAAAAGTTATTGGTCCTATGGATCTACTCATTGCAAGCCACGCAAAGTC
AAAGGGTCTTACCATTGTTACTAATAATACAAAAGAGTTTAAAAGAGTAAATCAATTAGAAGTTGAAGATTGGTCTAAAC
CATTAAGCTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8750.88 Da
• Isoelectric Point: 4.4217

>AT35318 WP_178885951.1 NZ_AP022321:2089222-2089452 [Veillonella nakazawae]
MTTAKLFENGRSQAVRLPKEFRFNGDEVIINKIGNVVLLMPKDDEWAGFVAGLSLFTDDFMYNGREDIDHQERETL

Nucleotide

• Length: 231 bp

>AT35318 NZ_AP022321:2089222-2089452 [Veillonella nakazawae]
ATGACCACAGCAAAGCTATTCGAAAATGGCCGCAGCCAGGCTGTACGATTACCAAAAGAATTTCGGTTTAATGGTGATGA
AGTAATCATCAACAAAATAGGAAATGTAGTTTTACTTATGCCAAAAGACGATGAGTGGGCAGGATTTGTAGCCGGTTTAT
CATTATTTACAGATGATTTTATGTATAACGGACGGGAAGATATTGATCATCAGGAGCGTGAAACCTTATGA