Detailed information of TA system TA035317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 440130..440607
• Replicon: chromosome
• Accession: NZ_AP022321
• Organism: Veillonella nakazawae strain T1-7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: VEIT17_RS01895
• Protein ID: WP_178884498.1
• Coordinates: 440341..440607 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C4FSP1
• Locus tag: VEIT17_RS01890
• Protein ID: WP_005387906.1
• Coordinates: 440130..440351 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VEIT17_RS01875	436074..437522	+	1449	WP_178884495.1	hypothetical protein	-
VEIT17_RS01880	437653..438174	+	522	WP_178884496.1	DUF4178 domain-containing protein	-
VEIT17_RS01885	438228..439601	-	1374	WP_060924140.1	MFS transporter	-
VEIT17_RS01890	440130..440351	+	222	WP_005387906.1	hypothetical protein	Antitoxin
VEIT17_RS01895	440341..440607	+	267	WP_178884498.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VEIT17_RS01900	440618..440830	+	213	WP_178884500.1	hypothetical protein	-
VEIT17_RS01905	440897..441982	+	1086	WP_178884501.1	hypothetical protein	-
VEIT17_RS01910	442077..442868	-	792	WP_178884503.1	carbon-nitrogen family hydrolase	-
VEIT17_RS01915	443135..443938	+	804	WP_178884505.1	polysaccharide deacetylase family protein	-
VEIT17_RS01920	443950..444888	+	939	WP_039969603.1	phosphodiester glycosidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-87)

Antitoxin

• Protein of unknown function DUF6290 (1-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10522.14 Da
• Isoelectric Point: 10.2849

>T35317 WP_178884498.1 NZ_AP022321:440341-440607 [Veillonella nakazawae]
MAYKLEFSKRFDKQFSKLDKSTQRYLFNWLIKNVDNVENPRYSGKSLIGSKTGLWRYRIGNYRVIADINDDRCIILALEV
GHRKDIYK

Nucleotide

• Length: 267 bp

>T35317 NZ_AP022321:440341-440607 [Veillonella nakazawae]
ATGGCTTATAAACTTGAGTTCTCTAAACGATTTGACAAGCAATTTTCTAAACTCGATAAATCAACACAACGTTATCTCTT
TAATTGGCTTATCAAGAACGTAGATAATGTAGAAAATCCTAGATATTCAGGAAAATCACTAATAGGTAGTAAGACAGGGC
TGTGGCGTTATCGCATTGGTAATTATAGAGTCATTGCTGATATTAATGATGATAGATGTATTATTTTAGCCTTAGAAGTG
GGGCACAGAAAAGATATTTACAAATAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8499.71 Da
• Isoelectric Point: 4.3700

>AT35317 WP_005387906.1 NZ_AP022321:440130-440351 [Veillonella nakazawae]
MANISVRLNEQEEELFKTYAEFMDETLSTLFKKALLEKIEDEFDLKVGQKALAEYKQDPVTYSVAEMRAKYGL

Nucleotide

• Length: 222 bp

>AT35317 NZ_AP022321:440130-440351 [Veillonella nakazawae]
ATGGCAAATATTTCAGTCCGTTTAAATGAACAAGAAGAAGAGTTATTTAAAACATATGCCGAGTTTATGGATGAAACACT
TTCTACTCTCTTTAAGAAGGCTTTACTAGAAAAGATTGAAGATGAATTTGATCTTAAGGTAGGTCAAAAAGCATTAGCAG
AATATAAGCAAGATCCTGTTACTTATTCTGTGGCGGAAATGCGTGCAAAATATGGCTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A2S7YQA8