35313

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 640522..641108 Replicon chromosome
Accession NZ_AP022317
Organism Burkholderia sp. THE68

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BTHE68_RS24260 Protein ID WP_162068829.1
Coordinates 640725..641108 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BTHE68_RS24255 Protein ID WP_162068828.1
Coordinates 640522..640728 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTHE68_RS24235 635593..636624 + 1032 WP_162068825.1 TRAP transporter substrate-binding protein -
BTHE68_RS24240 636639..638537 + 1899 WP_197919706.1 TRAP transporter large permease subunit -
BTHE68_RS24245 638550..639476 + 927 WP_162068826.1 amidohydrolase family protein -
BTHE68_RS24250 639488..640438 + 951 WP_162068827.1 amidohydrolase family protein -
BTHE68_RS24255 640522..640728 + 207 WP_162068828.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BTHE68_RS24260 640725..641108 + 384 WP_162068829.1 VapC toxin family PIN domain ribonuclease Toxin
BTHE68_RS36655 641162..641329 + 168 WP_167390482.1 hypothetical protein -
BTHE68_RS24265 641608..642546 + 939 WP_162068830.1 hypothetical protein -
BTHE68_RS24270 642566..643924 + 1359 WP_162068831.1 hypothetical protein -
BTHE68_RS24275 643977..646088 + 2112 WP_162069172.1 8-amino-7-oxononanoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14181.61 Da        Isoelectric Point: 6.4754

>T35313 WP_162068829.1 NZ_AP022317:640725-641108 [Burkholderia sp. THE68]
MTSVLIDTSVWVDHFRHRNAALVELIEWDRALTHPMVIGELACGTPPGPRVRTLSDIGLLRQAQQISVEEVMAFIEREAL
YGLGCGLVDLMLLGSVLMTPGAQIWTLDKRLMDISARFGVAYRPRVH

Download         Length: 384 bp

>T35313 NZ_AP022317:640725-641108 [Burkholderia sp. THE68]
ATGACGAGTGTGCTGATCGATACATCGGTGTGGGTGGATCACTTCCGTCATCGCAATGCTGCACTGGTCGAACTGATCGA
GTGGGATCGGGCGTTGACGCATCCGATGGTGATAGGCGAGCTGGCCTGCGGGACACCGCCCGGGCCGCGCGTGCGGACGT
TGAGCGATATTGGCCTGTTGCGGCAGGCTCAGCAGATCAGCGTTGAAGAGGTGATGGCGTTCATTGAGCGCGAAGCGCTT
TACGGGCTCGGCTGCGGACTGGTCGACCTGATGCTGCTGGGCTCGGTGTTGATGACACCCGGGGCGCAAATCTGGACGCT
CGATAAGCGCCTGATGGATATATCGGCGCGGTTTGGCGTGGCTTATCGGCCTCGCGTGCATTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7396.33 Da        Isoelectric Point: 4.7420

>AT35313 WP_162068828.1 NZ_AP022317:640522-640728 [Burkholderia sp. THE68]
VRTTVTLDDALYAKALEVADPEMDKSDLFREAIKTFVRVQAAKRLAALGGSAPEMGDIARRRDESDGS

Download         Length: 207 bp

>AT35313 NZ_AP022317:640522-640728 [Burkholderia sp. THE68]
GTGCGTACGACCGTGACGCTGGACGATGCGCTTTACGCAAAAGCGCTGGAGGTGGCTGATCCGGAAATGGACAAATCCGA
TCTCTTTCGGGAAGCGATCAAGACATTCGTGCGGGTGCAGGCGGCGAAGCGGCTTGCAGCATTGGGCGGGAGCGCGCCGG
AGATGGGTGATATTGCGCGTCGTCGTGACGAGTCGGACGGGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References