35312

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpB-mazE/PRK09812-MazE
Location 1155518..1156113 Replicon chromosome
Accession NZ_AP022316
Organism Burkholderia sp. THE68

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag BTHE68_RS18900 Protein ID WP_162067784.1
Coordinates 1155763..1156113 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BTHE68_RS18895 Protein ID WP_162068274.1
Coordinates 1155518..1155769 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTHE68_RS18880 1150992..1152899 - 1908 WP_162067781.1 selenocysteine-specific translation elongation factor -
BTHE68_RS18885 1152896..1154332 - 1437 WP_162067782.1 L-seryl-tRNA(Sec) selenium transferase -
BTHE68_RS18890 1154340..1155314 - 975 WP_162067783.1 formate dehydrogenase accessory protein FdhE -
BTHE68_RS18895 1155518..1155769 + 252 WP_162068274.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BTHE68_RS18900 1155763..1156113 + 351 WP_162067784.1 type II toxin-antitoxin system ChpB family toxin Toxin
BTHE68_RS18905 1156120..1156770 - 651 WP_162067785.1 formate dehydrogenase subunit gamma -
BTHE68_RS18910 1156757..1157701 - 945 WP_162067786.1 formate dehydrogenase subunit beta -
BTHE68_RS18915 1157712..1160780 - 3069 WP_162067787.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12331.17 Da        Isoelectric Point: 8.9951

>T35312 WP_162067784.1 NZ_AP022316:1155763-1156113 [Burkholderia sp. THE68]
MVRRAKFERGDIVRVNLNPTVGHEQQGEFRPALVLSSGVFNAMGVALVAPITQGGNFARFAGFAVPLAGDGIETQGVALV
NMIRTLDLEARGARKVERASVATTDDALARLQAILD

Download         Length: 351 bp

>T35312 NZ_AP022316:1155763-1156113 [Burkholderia sp. THE68]
ATGGTAAGGCGAGCCAAATTCGAACGCGGCGACATCGTGCGCGTGAACCTGAACCCGACCGTCGGCCATGAACAGCAAGG
CGAGTTCCGGCCCGCTCTCGTGCTCTCGTCGGGCGTGTTCAACGCCATGGGCGTCGCGCTCGTCGCGCCGATCACCCAAG
GCGGGAACTTCGCGCGCTTCGCCGGTTTCGCGGTCCCGCTTGCCGGCGACGGCATCGAAACACAAGGCGTCGCGCTGGTG
AACATGATCCGCACGCTCGATCTCGAAGCGCGGGGCGCGCGCAAGGTCGAGCGTGCGTCGGTCGCGACCACCGACGACGC
CCTCGCGCGGCTGCAGGCCATCCTCGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8944.36 Da        Isoelectric Point: 4.3821

>AT35312 WP_162068274.1 NZ_AP022316:1155518-1155769 [Burkholderia sp. THE68]
MKLSIQKWGNSAAVRLPAALLDQAKLELGDQLSVEVRPDGIMLTPARPSYALADLVAQCDFAAPMPEDLVAWNNLKPVGG
EAW

Download         Length: 252 bp

>AT35312 NZ_AP022316:1155518-1155769 [Burkholderia sp. THE68]
ATGAAACTCTCGATACAAAAGTGGGGCAACAGTGCCGCCGTGCGCTTGCCCGCCGCATTGCTGGATCAGGCGAAACTGGA
ACTCGGCGACCAGTTGAGCGTCGAGGTTCGTCCGGACGGCATCATGCTCACCCCGGCGCGACCCAGCTATGCCCTCGCCG
ATCTGGTCGCTCAATGCGATTTTGCAGCGCCTATGCCCGAAGACCTGGTCGCCTGGAACAACCTCAAGCCGGTGGGAGGT
GAAGCATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References