Detailed information of TA system TA035311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 619396..619874
• Replicon: chromosome
• Accession: NZ_AP022316
• Organism: Burkholderia sp. THE68

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BTHE68_RS16395
• Protein ID: WP_162067373.1
• Coordinates: 619590..619874 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BTHE68_RS16390
• Protein ID: WP_162067372.1
• Coordinates: 619396..619593 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTHE68_RS16370	615233..616972	+	1740	WP_162067368.1	FAD-dependent oxidoreductase	-
BTHE68_RS16375	616969..617580	+	612	WP_162067369.1	NIPSNAP family protein	-
BTHE68_RS16380	617595..618419	+	825	WP_162067370.1	sugar phosphate isomerase/epimerase	-
BTHE68_RS16385	618488..619297	+	810	WP_162067371.1	IclR family transcriptional regulator	-
BTHE68_RS16390	619396..619593	+	198	WP_162067372.1	stability determinant	Antitoxin
BTHE68_RS16395	619590..619874	+	285	WP_162067373.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTHE68_RS16400	619958..621421	+	1464	WP_162067374.1	cytochrome P450	-
BTHE68_RS16405	621428..622036	-	609	WP_162067375.1	XRE family transcriptional regulator	-
BTHE68_RS16410	622283..623782	+	1500	WP_162067376.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10735.46 Da
• Isoelectric Point: 9.4362

>T35311 WP_162067373.1 NZ_AP022316:619590-619874 [Burkholderia sp. THE68]
MTLQVVWTQTARLDFLEIIRYIAERSPSAARTIKNAIQAAPQSAAIAPYLYRHGRIPGTREIVVHPNYVVIYAVETDRIE
VLNVLHARQCYPFV

Nucleotide

• Length: 285 bp

>T35311 NZ_AP022316:619590-619874 [Burkholderia sp. THE68]
TTGACGCTGCAAGTTGTCTGGACTCAAACCGCGCGCCTCGACTTTCTGGAGATCATCCGATACATCGCTGAACGCAGTCC
CAGTGCCGCGCGCACGATCAAGAACGCGATTCAGGCAGCGCCGCAATCCGCCGCAATCGCCCCGTATCTTTACCGCCACG
GTCGTATTCCCGGAACGCGCGAAATCGTCGTTCATCCCAATTATGTTGTCATCTACGCGGTCGAGACGGACCGCATCGAA
GTGCTCAACGTGCTGCATGCGCGACAGTGCTATCCGTTCGTGTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7482.45 Da
• Isoelectric Point: 5.6939

>AT35311 WP_162067372.1 NZ_AP022316:619396-619593 [Burkholderia sp. THE68]
MPTPLDPIVSEFATVEEAEAYDKWFREKVRRSMADTRPRVPHDQVMAEAEAIITDAEKRHKSRAA

Nucleotide

• Length: 198 bp

>AT35311 NZ_AP022316:619396-619593 [Burkholderia sp. THE68]
ATGCCTACACCGCTCGATCCCATCGTGTCCGAGTTCGCCACTGTCGAAGAAGCGGAAGCTTATGACAAGTGGTTTCGCGA
GAAAGTACGCCGTTCGATGGCGGATACGCGGCCGCGCGTTCCGCATGACCAGGTGATGGCCGAGGCGGAAGCGATCATCA
CGGATGCCGAGAAACGTCACAAGTCGAGGGCCGCTTGA