35310

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Gp49-Ata
Location 357054..357659 Replicon chromosome
Accession NZ_AP022316
Organism Burkholderia sp. THE68

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag BTHE68_RS15140 Protein ID WP_162067158.1
Coordinates 357345..357659 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag BTHE68_RS15135 Protein ID WP_162067157.1
Coordinates 357054..357341 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTHE68_RS15115 352392..353507 - 1116 WP_162067155.1 succinylglutamate desuccinylase/aspartoacylase family protein -
BTHE68_RS15120 353700..354494 - 795 WP_061174550.1 ABC transporter substrate-binding protein -
BTHE68_RS15125 354697..356223 - 1527 WP_174258048.1 MFS transporter -
BTHE68_RS15130 356345..357034 + 690 WP_162067156.1 TetR/AcrR family transcriptional regulator -
BTHE68_RS15135 357054..357341 - 288 WP_162067157.1 helix-turn-helix domain-containing protein Antitoxin
BTHE68_RS15140 357345..357659 - 315 WP_162067158.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTHE68_RS15145 357811..358707 + 897 WP_162067159.1 ferritin-like domain-containing protein -
BTHE68_RS15150 358715..359440 - 726 WP_162067160.1 TetR/AcrR family transcriptional regulator -
BTHE68_RS15155 359615..360796 + 1182 WP_162067161.1 isovaleryl-CoA dehydrogenase -
BTHE68_RS15160 360808..362415 + 1608 WP_162067162.1 methylcrotonoyl-CoA carboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-81)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12093.93 Da        Isoelectric Point: 9.4576

>T35310 WP_162067158.1 NZ_AP022316:c357659-357345 [Burkholderia sp. THE68]
MKFLRFIGSALDDLRNFPAEARRETGFQLDAIQRGFMPDDFKPMPTVGMGAYEIRIHVEGEWRVLYVAKFEDAVYVLHAF
QKKAQKTPREDIELAARRYRQIGG

Download         Length: 315 bp

>T35310 NZ_AP022316:c357659-357345 [Burkholderia sp. THE68]
ATGAAATTTCTCCGCTTCATCGGCTCCGCTCTGGATGACCTGCGCAACTTTCCCGCTGAGGCGCGTCGTGAAACTGGTTT
TCAGCTAGACGCGATCCAACGCGGCTTCATGCCGGACGATTTCAAGCCCATGCCGACAGTCGGCATGGGAGCCTATGAGA
TCCGCATTCATGTCGAAGGCGAATGGCGCGTACTCTATGTCGCGAAATTCGAAGACGCAGTCTATGTGCTGCACGCGTTT
CAGAAGAAAGCACAGAAAACGCCCCGGGAAGACATCGAGCTCGCGGCACGCCGCTATCGCCAGATCGGAGGTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10393.97 Da        Isoelectric Point: 5.6726

>AT35310 WP_162067157.1 NZ_AP022316:c357341-357054 [Burkholderia sp. THE68]
MSESIIESSGNVFSDLGFSEEEATLLKLRADLMASLREVIVARGWTQAQAAQSLGLSQPRISDLTRGKWDKFSLDMLLAL
AVRVGLHPHIELKAA

Download         Length: 288 bp

>AT35310 NZ_AP022316:c357341-357054 [Burkholderia sp. THE68]
ATGAGCGAATCCATCATCGAATCGAGCGGCAACGTCTTCTCCGATCTCGGTTTCTCGGAAGAAGAAGCGACACTGCTCAA
ATTGCGCGCCGACCTCATGGCCTCGTTGCGGGAAGTCATTGTCGCGCGAGGCTGGACGCAGGCACAGGCCGCGCAATCGC
TCGGGCTCAGTCAGCCGCGCATTTCCGATCTGACTCGCGGAAAATGGGACAAATTCAGCCTCGATATGTTGCTGGCGCTC
GCGGTACGCGTCGGGCTGCATCCGCATATTGAGCTGAAAGCTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References