Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 827537..828221 Replicon chromosome
Accession NZ_AP022315
Organism Burkholderia sp. THE68

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag BTHE68_RS03950 Protein ID WP_162065228.1
Coordinates 827537..827905 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag BTHE68_RS03955 Protein ID WP_162066775.1
Coordinates 827898..828221 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTHE68_RS03940 822999..824978 + 1980 WP_162065226.1 type IIA DNA topoisomerase subunit B -
BTHE68_RS03945 825017..827335 + 2319 WP_162065227.1 DNA topoisomerase IV subunit A -
BTHE68_RS03950 827537..827905 + 369 WP_162065228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTHE68_RS03955 827898..828221 + 324 WP_162066775.1 helix-turn-helix domain-containing protein Antitoxin
BTHE68_RS03960 828228..828494 - 267 WP_162065229.1 hypothetical protein -
BTHE68_RS03965 828733..829191 + 459 WP_162065230.1 CopD family protein -
BTHE68_RS03970 829212..831641 - 2430 WP_162065231.1 EAL domain-containing protein -
BTHE68_RS03975 832036..832926 - 891 WP_162065232.1 PhzF family phenazine biosynthesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-110)

Antitoxin

HigA2-like, helix-turn-helix domain

(11-89)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13575.54 Da        Isoelectric Point: 10.0648

>T35308 WP_162065228.1 NZ_AP022315:827537-827905 [Burkholderia sp. THE68]
MEEREVKPLRWVGSAKRDLKTMPADVQDMFGFALYQAQSGRKHEQAKPLKGFGSAGVLEVVESSKDGAFRAVYTVRFEHA
VYVLHCFQKKSASGIATPRPDMEIIRARLKAAQAHAAGERND

Download         Length: 369 bp

>T35308 NZ_AP022315:827537-827905 [Burkholderia sp. THE68]
ATGGAAGAGCGAGAAGTCAAGCCGCTGCGATGGGTGGGTTCCGCGAAGCGAGACCTGAAGACAATGCCAGCGGACGTGCA
GGACATGTTTGGCTTTGCGCTGTATCAGGCGCAGTCCGGCAGAAAGCACGAACAGGCGAAGCCGTTGAAGGGATTCGGAT
CTGCAGGCGTGCTGGAAGTCGTGGAATCGTCGAAGGATGGTGCTTTTCGCGCGGTCTATACGGTGAGATTCGAGCACGCG
GTTTATGTGTTGCACTGTTTCCAGAAGAAATCGGCATCTGGCATCGCCACACCGAGACCGGATATGGAGATCATCCGGGC
GCGGCTGAAAGCGGCCCAGGCCCATGCAGCGGGAGAGCGCAATGATTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11751.69 Da        Isoelectric Point: 10.7886

>AT35308 WP_162066775.1 NZ_AP022315:827898-828221 [Burkholderia sp. THE68]
MIEIEDSSGNVYADLGLPDADEMRVKAQLAGKIGEIIKTRRWTQQRAADVLGISQPKLSQLLRGQFRGISEAKMLELLAR
LGRNVQIVVGPPRRSAKPGRVEVVFAA

Download         Length: 324 bp

>AT35308 NZ_AP022315:827898-828221 [Burkholderia sp. THE68]
ATGATTGAGATAGAAGATAGCAGCGGCAACGTGTACGCTGACCTGGGACTGCCCGATGCCGACGAAATGCGCGTCAAGGC
GCAACTCGCCGGCAAGATTGGCGAAATCATCAAGACCCGGCGCTGGACGCAGCAACGTGCCGCTGATGTTCTCGGCATCA
GCCAACCCAAGCTCTCGCAACTGCTGCGCGGCCAGTTTCGGGGCATCAGCGAAGCGAAGATGCTCGAGTTGCTCGCGCGC
CTTGGCCGCAATGTGCAAATCGTCGTCGGTCCGCCGCGGCGCTCGGCCAAGCCAGGCCGCGTGGAAGTCGTGTTCGCCGC
CTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References