35307

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 791468..792081 Replicon chromosome
Accession NZ_AP022315
Organism Burkholderia sp. THE68

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BTHE68_RS03745 Protein ID WP_162065196.1
Coordinates 791468..791668 (+) Length 67 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BTHE68_RS03750 Protein ID WP_162065197.1
Coordinates 791680..792081 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTHE68_RS03730 787550..787798 + 249 WP_162065193.1 hypothetical protein -
BTHE68_RS03735 788164..789927 + 1764 WP_162065194.1 ABC transporter permease subunit -
BTHE68_RS03740 789949..791295 + 1347 WP_174258027.1 nitrate/sulfonate/bicarbonate ABC transporter ATP-binding protein -
BTHE68_RS03745 791468..791668 + 201 WP_162065196.1 type II toxin-antitoxin system HicA family toxin Toxin
BTHE68_RS03750 791680..792081 + 402 WP_162065197.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BTHE68_RS03755 792141..792665 - 525 WP_162065198.1 hypothetical protein -
BTHE68_RS03760 792662..793216 - 555 WP_162065199.1 hypothetical protein -
BTHE68_RS03765 793496..794563 - 1068 WP_162065200.1 sigma-54 dependent transcriptional regulator -
BTHE68_RS03770 795147..795488 + 342 WP_162065201.1 hypothetical protein -
BTHE68_RS03775 795547..795864 + 318 WP_162065202.1 DUF883 family protein -
BTHE68_RS03780 795905..796141 + 237 WP_162065203.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7489.70 Da        Isoelectric Point: 11.8155

>T35307 WP_162065196.1 NZ_AP022315:791468-791668 [Burkholderia sp. THE68]
MESSRLIRMLLDDGWELVRIRGSHHHFSHRTKNGRVTVVHPKKDVAIGTVRSVLKGAGLLNRLYSS

Download         Length: 201 bp

>T35307 NZ_AP022315:791468-791668 [Burkholderia sp. THE68]
ATGGAGTCATCGCGCTTGATACGAATGCTGCTGGATGATGGTTGGGAGCTGGTTCGCATCCGGGGCAGTCATCATCATTT
CAGTCACAGGACCAAGAACGGTCGCGTGACCGTGGTTCATCCAAAGAAAGACGTGGCGATCGGGACAGTCAGATCAGTGC
TGAAAGGCGCCGGATTGCTCAACCGTCTGTATTCGTCGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14714.60 Da        Isoelectric Point: 4.3097

>AT35307 WP_162065197.1 NZ_AP022315:791680-792081 [Burkholderia sp. THE68]
MEFALAIHKDPESCYGVTVPNVPGVFSAGDTIDEAIQNAREAIFFHIETIIEDGVEVSITSRSIEELIVDPDFAGAIWAY
VEVDLSKLDSRPERINISLPRFVLHKIDSYVEARHETRSGFLARVALEAIANG

Download         Length: 402 bp

>AT35307 NZ_AP022315:791680-792081 [Burkholderia sp. THE68]
ATGGAATTTGCCCTCGCCATTCACAAAGATCCCGAAAGCTGCTACGGCGTGACCGTGCCCAATGTGCCCGGCGTTTTCTC
CGCCGGCGACACGATCGACGAAGCGATTCAAAATGCCAGAGAAGCTATCTTTTTCCACATCGAGACGATTATCGAAGACG
GCGTGGAAGTCTCGATCACGTCGCGGAGCATCGAGGAACTGATCGTCGATCCCGACTTCGCCGGCGCAATCTGGGCCTAC
GTCGAAGTCGATCTGTCGAAGCTCGATTCGCGGCCGGAGCGCATCAACATCAGCCTTCCGCGTTTCGTGCTGCACAAGAT
CGACAGCTACGTCGAGGCGCGCCACGAGACGCGCAGTGGTTTTCTCGCGCGCGTCGCGCTGGAGGCGATTGCGAACGGCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References