Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/-
Location 4148247..4148760 Replicon chromosome
Accession NZ_AP022314
Organism Mycobacterium xenopi strain JCM 15661

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MYXE_RS19785 Protein ID WP_085195270.1
Coordinates 4148247..4148528 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MYXE_RS19790 Protein ID WP_085195305.1
Coordinates 4148515..4148760 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYXE_RS19745 4143724..4144518 - 795 WP_085195281.1 hypothetical protein -
MYXE_RS19750 4144703..4144882 - 180 WP_085195279.1 hypothetical protein -
MYXE_RS19755 4144882..4145316 - 435 WP_083088679.1 type II toxin-antitoxin system VapC family toxin -
MYXE_RS19760 4145313..4145609 - 297 WP_085195277.1 toxin-antitoxin system HicB family antitoxin -
MYXE_RS19765 4145919..4146302 - 384 WP_085195307.1 nuclear transport factor 2 family protein -
MYXE_RS19770 4146552..4146821 - 270 WP_085195275.1 hypothetical protein -
MYXE_RS19775 4147538..4147864 - 327 WP_003919576.1 type II toxin-antitoxin system PemK/MazF family toxin -
MYXE_RS19780 4147861..4148082 - 222 WP_085195272.1 antitoxin MazE family protein -
MYXE_RS19785 4148247..4148528 - 282 WP_085195270.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MYXE_RS19790 4148515..4148760 - 246 WP_085195305.1 ribbon-helix-helix protein, CopG family Antitoxin
MYXE_RS19795 4148990..4149325 - 336 WP_085195268.1 DUF86 domain-containing protein -
MYXE_RS19800 4149315..4149620 - 306 WP_085195266.1 nucleotidyltransferase domain-containing protein -
MYXE_RS19805 4149859..4152171 - 2313 WP_085195264.1 GH92 family glycosyl hydrolase -
MYXE_RS19810 4152239..4153114 - 876 WP_085195262.1 hypothetical protein -
MYXE_RS19815 4153173..4153390 + 218 Protein_3936 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10302.86 Da        Isoelectric Point: 11.4226

>T35304 WP_085195270.1 NZ_AP022314:c4148528-4148247 [Mycobacterium xenopi]
MRHGELWFAATPGGDRPVLVLTRDLVTALTRTRRGLVSELELTAVQDGVPSDCFVNFDNVHTLPRTAFRRRITRLSAVGL
HQACRTLRASTGC

Download         Length: 282 bp

>T35304 NZ_AP022314:c4148528-4148247 [Mycobacterium xenopi]
ATGCGGCACGGTGAATTATGGTTCGCCGCCACCCCTGGCGGTGATCGCCCCGTGCTTGTTCTCACCAGGGATCTCGTCAC
CGCGCTGACCCGAACCCGCAGGGGACTGGTGTCGGAACTGGAATTGACGGCGGTTCAGGACGGCGTGCCAAGCGATTGCT
TCGTCAACTTCGACAACGTTCATACGCTGCCGCGTACCGCATTTCGCCGCAGGATCACACGCTTGTCCGCGGTAGGTCTC
CACCAAGCGTGCCGCACCCTGCGGGCAAGCACCGGATGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9294.20 Da        Isoelectric Point: 4.2669

>AT35304 WP_085195305.1 NZ_AP022314:c4148760-4148515 [Mycobacterium xenopi]
MISFRVDDADAAAIDEWARRLHVERSELIRDALRHHLAQLAADQDVRAYIEHPMTDEERALAEVADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT35304 NZ_AP022314:c4148760-4148515 [Mycobacterium xenopi]
ATGATCAGCTTTCGGGTCGACGACGCGGACGCGGCCGCAATCGACGAGTGGGCGCGGCGGCTGCACGTCGAGCGGTCTGA
GCTCATTCGCGATGCGCTGCGCCACCATTTGGCTCAGCTTGCAGCCGACCAGGACGTGCGCGCGTACATCGAGCACCCCA
TGACGGACGAGGAAAGGGCGCTCGCCGAGGTCGCCGATTGGGGCCCCGCAGAGGACTGGGCTGACTGGGCCGATGCGGCA
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References