Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2490968..2491512 Replicon chromosome
Accession NZ_AP022314
Organism Mycobacterium xenopi strain JCM 15661

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MYXE_RS11585 Protein ID WP_085194516.1
Coordinates 2490968..2491246 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MYXE_RS11590 Protein ID WP_085194519.1
Coordinates 2491243..2491512 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYXE_RS11550 2486502..2487960 + 1459 Protein_2296 DDE-type integrase/transposase/recombinase -
MYXE_RS11555 2487957..2488773 + 817 Protein_2297 ExeA family protein -
MYXE_RS11560 2489000..2489248 + 249 WP_039891297.1 ribbon-helix-helix protein, CopG family -
MYXE_RS11565 2489242..2489586 + 345 WP_003922982.1 type II toxin-antitoxin system PemK/MazF family toxin -
MYXE_RS11570 2489854..2490212 + 359 Protein_2300 nuclear transport factor 2 family protein -
MYXE_RS24015 2490226..2490366 - 141 WP_197904862.1 hypothetical protein -
MYXE_RS11580 2490563..2490781 - 219 WP_085194514.1 HNH endonuclease -
MYXE_RS11585 2490968..2491246 - 279 WP_085194516.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYXE_RS11590 2491243..2491512 - 270 WP_085194519.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MYXE_RS23605 2491607..2491960 + 354 WP_085194521.1 hypothetical protein -
MYXE_RS11595 2492251..2492679 - 429 WP_003918897.1 cellulose-binding domain-containing protein -
MYXE_RS11600 2492964..2493950 + 987 WP_039889418.1 peroxiredoxin -
MYXE_RS11605 2494385..2495866 + 1482 WP_003918895.1 biotin carboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10733.39 Da        Isoelectric Point: 11.2606

>T35302 WP_085194516.1 NZ_AP022314:c2491246-2490968 [Mycobacterium xenopi]
VTEPHTQWSVQLSPSAVRALDRLPHKVAAAIVEFVTVTLPIDPYRLSKPLRFEFEGWRVARRGDYRVTFRALTDGHVLFI
GRIEHRAHVYRR

Download         Length: 279 bp

>T35302 NZ_AP022314:c2491246-2490968 [Mycobacterium xenopi]
GTGACCGAACCGCACACACAGTGGTCCGTCCAATTGTCGCCATCGGCGGTGCGCGCCCTCGACCGGCTGCCACACAAAGT
CGCCGCGGCGATCGTCGAATTCGTCACCGTTACATTGCCCATCGACCCATACCGGCTATCGAAACCGCTGCGGTTCGAGT
TCGAAGGCTGGCGTGTGGCGCGCCGCGGTGACTACCGCGTCACCTTCCGTGCACTCACCGACGGCCACGTGCTCTTCATC
GGCCGCATTGAACACCGCGCGCATGTCTACCGCCGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9688.86 Da        Isoelectric Point: 4.6627

>AT35302 WP_085194519.1 NZ_AP022314:c2491512-2491243 [Mycobacterium xenopi]
MKTVPLTEAKDKLSALVDEADTTHEIIQITRHGRVAAVIMSADDLESLNETLHALRTPGVAEELKQADADYAAGNTVSGE
EIRQRYGLK

Download         Length: 270 bp

>AT35302 NZ_AP022314:c2491512-2491243 [Mycobacterium xenopi]
ATGAAGACGGTCCCGCTGACCGAGGCCAAAGACAAGCTTTCCGCGCTCGTCGACGAAGCCGACACCACCCACGAAATCAT
TCAGATCACCCGGCACGGCCGGGTCGCAGCGGTCATCATGTCCGCCGACGACCTCGAATCGCTCAACGAGACCCTGCACG
CGCTGCGCACCCCGGGCGTCGCCGAGGAGCTCAAGCAGGCCGACGCCGACTACGCGGCCGGCAACACCGTCAGCGGCGAG
GAGATTCGCCAGCGCTATGGCCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References