Detailed information of TA system TA035298

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2923362..2924040
• Replicon: chromosome
• Accession: NZ_AP022302
• Organism: Acinetobacter sp. BEC1-S18-ESBL-01

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: H7R46_RS13765
• Protein ID: WP_057077657.1
• Coordinates: 2923858..2924040 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H7R46_RS13760
• Protein ID: WP_057077658.1
• Coordinates: 2923362..2923766 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R46_RS13755	2922527..2923216	-	690	WP_057077659.1	hypothetical protein	-
H7R46_RS13760	2923362..2923766	-	405	WP_057077658.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H7R46_RS13765	2923858..2924040	-	183	WP_057077657.1	type II toxin-antitoxin system HicA family toxin	Toxin
H7R46_RS13770	2924109..2924315	-	207	WP_171258791.1	hypothetical protein	-
H7R46_RS13775	2924372..2924905	-	534	WP_057077656.1	hypothetical protein	-
H7R46_RS13780	2924952..2925881	-	930	WP_057077655.1	hypothetical protein	-
H7R46_RS13785	2925990..2926202	-	213	WP_057077654.1	hypothetical protein	-
H7R46_RS13790	2926209..2926412	-	204	WP_057077653.1	hypothetical protein	-
H7R46_RS13795	2926414..2926812	-	399	WP_057077652.1	hypothetical protein	-
H7R46_RS13800	2926814..2927182	-	369	WP_057077651.1	hypothetical protein	-
H7R46_RS13805	2927148..2927558	-	411	WP_086225809.1	hypothetical protein	-
H7R46_RS13810	2927570..2927740	-	171	WP_164528213.1	hypothetical protein	-
H7R46_RS13815	2927743..2928009	-	267	WP_086225808.1	hypothetical protein	-
H7R46_RS13820	2928009..2928377	-	369	WP_086225807.1	glutamate 5-kinase	-
H7R46_RS13825	2928377..2928754	-	378	WP_057090125.1	hypothetical protein	-
H7R46_RS13830	2928758..2929039	-	282	WP_057090138.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2883389..2959891	76502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6682.84 Da
• Isoelectric Point: 10.5523

>T35298 WP_057077657.1 NZ_AP022302:c2924040-2923858 [Acinetobacter sp. BEC1-S18-ESBL-01]
VKSLDLIKMIEADGWYEVRVTGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T35298 NZ_AP022302:c2924040-2923858 [Acinetobacter sp. BEC1-S18-ESBL-01]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTACAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGGTTAGTAACAATCCCGCATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14720.74 Da
• Isoelectric Point: 4.3819

>AT35298 WP_057077658.1 NZ_AP022302:c2923766-2923362 [Acinetobacter sp. BEC1-S18-ESBL-01]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENIKEAISGHLEILAEDGEEIPEASELIKFIDDADYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT35298 NZ_AP022302:c2923766-2923362 [Acinetobacter sp. BEC1-S18-ESBL-01]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACCGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGATACACTTGAAGAAGCTATTGAAAATATTAAAGAAGCTATTTCAGGTCATTTAGAAATCTTAGCTGAAG
ATGGAGAGGAAATTCCTGAAGCTTCAGAATTGATTAAATTTATAGATGATGCTGACTATAAGGGTATGATCTGGGCAGTG
ACCGAGGTTGATGTAAGCCGCTATCTAGGTAAGCCTGAAAAAATCAATGTTACTTTGCCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTAGGTAAGGATAAAAGATTTAAAACCCGATCTGCATTTTTGGCCGCCGGTGCTGAAAAGCTACTACATG
CTTAA