Detailed information of TA system TA035297

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2557825..2558504
• Replicon: chromosome
• Accession: NZ_AP022302
• Organism: Acinetobacter sp. BEC1-S18-ESBL-01

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: H7R46_RS12070
• Protein ID: WP_000838146.1
• Coordinates: 2558322..2558504 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: H7R46_RS12065
• Protein ID: WP_000966688.1
• Coordinates: 2557825..2558229 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R46_RS12055	2556781..2557044	-	264	WP_001275792.1	hypothetical protein	-
H7R46_RS12060	2557046..2557726	-	681	WP_000721572.1	hypothetical protein	-
H7R46_RS12065	2557825..2558229	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H7R46_RS12070	2558322..2558504	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
H7R46_RS12075	2558830..2559345	-	516	WP_025464105.1	hypothetical protein	-
H7R46_RS12080	2559416..2560333	-	918	WP_002121543.1	hypothetical protein	-
H7R46_RS12085	2560386..2561714	-	1329	WP_182924209.1	hypothetical protein	-
H7R46_RS12090	2561761..2562216	-	456	WP_001136775.1	hypothetical protein	-
H7R46_RS12095	2562879..2563115	-	237	WP_000152665.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2534120..2570616	36496

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T35297 WP_000838146.1 NZ_AP022302:c2558504-2558322 [Acinetobacter sp. BEC1-S18-ESBL-01]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T35297 NZ_AP022302:c2558504-2558322 [Acinetobacter sp. BEC1-S18-ESBL-01]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT35297 WP_000966688.1 NZ_AP022302:c2558229-2557825 [Acinetobacter sp. BEC1-S18-ESBL-01]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT35297 NZ_AP022302:c2558229-2557825 [Acinetobacter sp. BEC1-S18-ESBL-01]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6