Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 463212..463865 Replicon chromosome
Accession NZ_AP022302
Organism Acinetobacter sp. BEC1-S18-ESBL-01

Toxin (Protein)


Gene name cptA Uniprot ID A0A009QSR1
Locus tag H7R46_RS02270 Protein ID WP_005067287.1
Coordinates 463476..463865 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A009HHW9
Locus tag H7R46_RS02265 Protein ID WP_002117064.1
Coordinates 463212..463469 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R46_RS02245 458725..459732 + 1008 WP_002116730.1 DNA-directed RNA polymerase subunit alpha -
H7R46_RS02250 459751..460128 + 378 WP_002049717.1 50S ribosomal protein L17 -
H7R46_RS02255 460310..461800 + 1491 WP_005067285.1 NAD(P)/FAD-dependent oxidoreductase -
H7R46_RS02260 461851..463023 - 1173 WP_005067286.1 acyl-CoA dehydrogenase family protein -
H7R46_RS02265 463212..463469 + 258 WP_002117064.1 succinate dehydrogenase assembly factor 2 Antitoxin
H7R46_RS02270 463476..463865 + 390 WP_005067287.1 hypothetical protein Toxin
H7R46_RS02275 464636..465724 + 1089 WP_005067288.1 hypothetical protein -
H7R46_RS02280 465808..466383 + 576 WP_005067290.1 rhombosortase -
H7R46_RS02285 466565..468760 + 2196 WP_005067292.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15505.61 Da        Isoelectric Point: 8.7390

>T35296 WP_005067287.1 NZ_AP022302:463476-463865 [Acinetobacter sp. BEC1-S18-ESBL-01]
MIKELNFELKYSRVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSVAYFSKKEI
YRGEITKIIDYQLFVVIYLEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Download         Length: 390 bp

>T35296 NZ_AP022302:463476-463865 [Acinetobacter sp. BEC1-S18-ESBL-01]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCGTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTAGGTTTAGC
AATCCTGCTTTATCAATTATTAACGCCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCTCAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTTTCGAAAAAAGAAATT
TACCGTGGGGAAATTACTAAAATAATTGATTATCAGTTATTTGTGGTTATTTATCTTGAAGAAACTCCTACGAACATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10295.73 Da        Isoelectric Point: 4.4809

>AT35296 WP_002117064.1 NZ_AP022302:463212-463469 [Acinetobacter sp. BEC1-S18-ESBL-01]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Download         Length: 258 bp

>AT35296 NZ_AP022302:463212-463469 [Acinetobacter sp. BEC1-S18-ESBL-01]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAACTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGTTAGTCGATCAAGAAG
ATCCGGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTACATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009QSR1

Antitoxin

Source ID Structure
AlphaFold DB A0A009HHW9

References