Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 3059054..3059525 | Replicon | chromosome |
| Accession | NZ_AP022298 | ||
| Organism | Escherichia coli strain BEC1-S17-ESBL-09 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | H7R48_RS14770 | Protein ID | WP_001303511.1 |
| Coordinates | 3059247..3059525 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | H7R48_RS14765 | Protein ID | WP_001302048.1 |
| Coordinates | 3059054..3059245 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H7R48_RS14705 | 3054241..3054504 | - | 264 | WP_000224221.1 | hypothetical protein | - |
| H7R48_RS14710 | 3054506..3054997 | - | 492 | WP_001167293.1 | hypothetical protein | - |
| H7R48_RS14715 | 3055000..3055359 | - | 360 | WP_001289987.1 | hypothetical protein | - |
| H7R48_RS14720 | 3055356..3055532 | - | 177 | WP_021534704.1 | hypothetical protein | - |
| H7R48_RS14725 | 3055525..3055707 | - | 183 | WP_001224665.1 | hypothetical protein | - |
| H7R48_RS14730 | 3055836..3056147 | - | 312 | WP_021534703.1 | hypothetical protein | - |
| H7R48_RS14735 | 3056140..3056394 | - | 255 | WP_000004322.1 | hypothetical protein | - |
| H7R48_RS14740 | 3056391..3056813 | - | 423 | WP_021534702.1 | DUF977 family protein | - |
| H7R48_RS14745 | 3056854..3057816 | - | 963 | WP_000095673.1 | helix-turn-helix domain-containing protein | - |
| H7R48_RS14750 | 3057839..3058264 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| H7R48_RS14755 | 3058261..3058563 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| H7R48_RS14760 | 3058662..3059033 | + | 372 | WP_001169687.1 | hypothetical protein | - |
| H7R48_RS14765 | 3059054..3059245 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| H7R48_RS14770 | 3059247..3059525 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H7R48_RS14775 | 3059817..3059969 | + | 153 | WP_000380313.1 | DUF1391 family protein | - |
| H7R48_RS14780 | 3059981..3060319 | + | 339 | WP_000394541.1 | hypothetical protein | - |
| H7R48_RS14785 | 3060308..3060574 | - | 267 | WP_012601410.1 | hypothetical protein | - |
| H7R48_RS14790 | 3061069..3061257 | + | 189 | WP_000449172.1 | cell division inhibitor | - |
| H7R48_RS14795 | 3061254..3061442 | + | 189 | WP_000199480.1 | DUF1482 family protein | - |
| H7R48_RS14800 | 3061538..3064009 | + | 2472 | WP_032284123.1 | exonuclease | - |
| H7R48_RS14805 | 3064071..3064340 | + | 270 | WP_000003742.1 | excisionase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3013224..3069691 | 56467 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T35269 WP_001303511.1 NZ_AP022298:3059247-3059525 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T35269 NZ_AP022298:3059247-3059525 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT35269 WP_001302048.1 NZ_AP022298:3059054-3059245 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT35269 NZ_AP022298:3059054-3059245 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|