Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
Location | 29568..30127 | Replicon | plasmid pBEC1-S17-ESBL-07_1 |
Accession | NZ_AP022296 | ||
Organism | Escherichia coli strain BEC1-S17-ESBL-07 |
Toxin (Protein)
Gene name | relE | Uniprot ID | S1PMX5 |
Locus tag | H7R29_RS22395 | Protein ID | WP_000421257.1 |
Coordinates | 29568..29843 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | U9Y625 |
Locus tag | H7R29_RS22400 | Protein ID | WP_001178087.1 |
Coordinates | 29843..30127 (-) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H7R29_RS22365 | 25640..25894 | + | 255 | WP_000343106.1 | hypothetical protein | - |
H7R29_RS22370 | 25894..26484 | + | 591 | WP_001401589.1 | hypothetical protein | - |
H7R29_RS22375 | 26697..27749 | + | 1053 | WP_000655519.1 | hypothetical protein | - |
H7R29_RS22380 | 27925..28527 | + | 603 | WP_000521606.1 | hypothetical protein | - |
H7R29_RS22385 | 28665..28931 | + | 267 | WP_000627831.1 | hypothetical protein | - |
H7R29_RS22390 | 29122..29403 | - | 282 | WP_001105066.1 | hypothetical protein | - |
H7R29_RS22395 | 29568..29843 | - | 276 | WP_000421257.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
H7R29_RS22400 | 29843..30127 | - | 285 | WP_001178087.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
H7R29_RS22405 | 31032..31904 | - | 873 | WP_000729438.1 | incFII family plasmid replication initiator RepA | - |
H7R29_RS22410 | 32607..33248 | + | 642 | WP_021515453.1 | hypothetical protein | - |
H7R29_RS22415 | 33388..34050 | + | 663 | WP_005082527.1 | hypothetical protein | - |
H7R29_RS22420 | 34317..34460 | + | 144 | WP_000176500.1 | hypothetical protein | - |
H7R29_RS22425 | 34541..34783 | + | 243 | WP_021515452.1 | PilI type IV pilus biogenesis protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | mph(A) / blaCTX-M-14 | - | 1..105884 | 105884 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10749.45 Da Isoelectric Point: 9.9324
>T35253 WP_000421257.1 NZ_AP022296:c29843-29568 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T35253 NZ_AP022296:c29843-29568 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAATCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAATCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10488.92 Da Isoelectric Point: 5.6558
>AT35253 WP_001178087.1 NZ_AP022296:c30127-29843 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR
Download Length: 285 bp
>AT35253 NZ_AP022296:c30127-29843 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCTCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCTCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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