35232

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 66105..67458 Replicon plasmid pWP9-W18-ESBL-04_1
Accession NZ_AP022291
Organism Aeromonas veronii strain WP9-W18-ESBL-04

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1Z3MNN1
Locus tag H7R81_RS22445 Protein ID WP_005321447.1
Coordinates 66105..67070 (-) Length 322 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A807ZF76
Locus tag H7R81_RS22450 Protein ID WP_042468273.1
Coordinates 67060..67458 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R81_RS22415 61682..62227 - 546 WP_182971136.1 recombinase family protein -
H7R81_RS22420 62255..62956 - 702 WP_182936412.1 RNA ligase family protein -
H7R81_RS22425 62960..63493 - 534 WP_182936411.1 hypothetical protein -
H7R81_RS22430 63474..64883 - 1410 WP_182936410.1 DUF3696 domain-containing protein -
H7R81_RS22435 65314..65499 - 186 WP_005321442.1 hypothetical protein -
H7R81_RS22440 65629..65781 - 153 WP_005321445.1 type I toxin-antitoxin system Hok family toxin -
H7R81_RS22445 66105..67070 - 966 WP_005321447.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
H7R81_RS22450 67060..67458 - 399 WP_042468273.1 S-adenosylhomocysteine hydrolase Antitoxin
H7R81_RS22455 68395..68841 + 447 WP_063968044.1 DNA repair protein RadC -
H7R81_RS22460 68881..69243 + 363 WP_182936413.1 DNA repair protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..131195 131195


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(43-302)

Antitoxin

Protein of unknown function DUF6088

(7-128)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 36512.59 Da        Isoelectric Point: 5.1489

>T35232 WP_005321447.1 NZ_AP022291:c67070-66105 [Aeromonas veronii]
MQPKDSSIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHYCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVERAEVTCRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQEPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHEL
I

Download         Length: 966 bp

>T35232 NZ_AP022291:c67070-66105 [Aeromonas veronii]
ATGCAGCCTAAAGACTCTTCGATTTTCGCCGACGTTTCTGACTACTTCGGGATCGATAACCCTGCGATAGCAGAAAAGGA
CTACTACGTCGTCCAGCTGCTCAAACTGCTTGCAAGTCATTATTGCCAGCACCACACCATGGTGTTTGCAGGCGGGACCG
CATTAGCCAAAGCTGACGTCAAGCTTCAGCGCATGTCTGAAGATGTCGACATCAAGTTATCTGTTAACGATAGTGCTAAA
GATGAATCTCGAAGCGCGATGAAGCGCCATCGCAAAGCCATCCGAGATGGTTTGATTGAAGAGCTCAATGCGACTGGCGT
TTTCCAAGTAGAGAGGGCTGAGGTCACTTGTCGGGATGAGCACAGGTACATTGAAATGCCGGTGAGATACCCGCAGGCCT
TCAGCAAGGCCCCCTGCCTTCGGCCTTTCATCAAGCTCGAACTCATTGAGACTGATCTGCTTGCAGGCCATAACCCCATG
CCCATTTGTTCGCTGCACAATGAAGCGATGCAGCAAGAACCTGAAGTGCCAGCCTTCAACACGGTTCCCCTGATCTCCAC
CCAAGCCGAGAAAGTGTTGTCGATGCTGCGCAGAACAGCCAGCGTCAAGCATGACCCAGAACGATTGGATGATGAGTCGT
TGGTTCGCCACATTTATGACACTTATCGCCTGCAACAAAGTACCACCTTTGATTTGGCCGAACTGGCAGGGCTGATAGCT
GAAGGGATGAAGATGGATCGTGATCGCTATGGTCCCCAACACCCCGAGTTTGCAGCAGATCCTATCGGTGTGATGCGGTT
TGGCCTGGATGTGATTGCTGGTGACCCCCTATACAAAGATCGTTATGAGGCATTCGTGAAGCCGATGGTGTATGGGGATG
CGTTGACTTGGGATGAGGCATTTCGCGTGTTCGAGGCTGTTGCGCGCCAGGCTCTAGATCACATTGAGCAACACGAACTT
ATTTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14761.36 Da        Isoelectric Point: 11.0142

>AT35232 WP_042468273.1 NZ_AP022291:c67458-67060 [Aeromonas veronii]
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQVPAFMEVKPKKRFSRKLKIGSRVFNAA

Download         Length: 399 bp

>AT35232 NZ_AP022291:c67458-67060 [Aeromonas veronii]
ATGACCATTGCTGACCGTGTTGAAGCACGAATCAAACGATCTAAGCGAGATGTGTTTCTCCGTGAGGATTTCGATGACTT
GGGCGGTTATGACCAAATAGGCAGAGCTTTACGCCAGATGTGTGAAAAGGGTCTGCTTCTGAAGGTCGGCTACGGCGTGT
ATGCAAAGGCACGGCGTAACCGGATCAATAGTCGCTTGATGATCGCCTCCCCTGGTGGTCCAGACGCCGTACTCATTGCT
ACGCTTGACCGCCTGAAGGTGCCTTACGAACTGAAGGGCCTGACCGCAGCTTATGCCGCGGGGAAATCCACTCAGGTTCC
CGCCTTTATGGAAGTTAAGCCTAAAAAGCGTTTTTCCAGAAAGCTGAAAATAGGAAGCCGAGTGTTCAATGCAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z3MNN1

Antitoxin

Source ID Structure
AlphaFold DB A0A807ZF76

References