Detailed information of TA system TA035230

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 3053171..3053748
• Replicon: chromosome
• Accession: NZ_AP022290
• Organism: Aeromonas veronii strain WP9-W18-ESBL-04

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: H7R81_RS13915
• Protein ID: WP_182969249.1
• Coordinates: 3053350..3053748 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: H7R81_RS13910
• Protein ID: WP_182969248.1
• Coordinates: 3053171..3053350 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R81_RS13875	3049390..3049638	-	249	WP_182969244.1	hypothetical protein	-
H7R81_RS22880	3049635..3050459	-	825	WP_197971605.1	hypothetical protein	-
H7R81_RS13885	3050456..3051274	-	819	WP_182969245.1	KilA-N domain-containing protein	-
H7R81_RS13890	3051350..3051529	-	180	WP_158656151.1	hypothetical protein	-
H7R81_RS13895	3051730..3052170	+	441	WP_182969246.1	hypothetical protein	-
H7R81_RS13900	3052183..3052839	+	657	WP_182969247.1	hypothetical protein	-
H7R81_RS13905	3052841..3053026	-	186	WP_128297137.1	hypothetical protein	-
H7R81_RS13910	3053171..3053350	+	180	WP_182969248.1	hypothetical protein	Antitoxin
H7R81_RS13915	3053350..3053748	+	399	WP_182969249.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nueA	3020922..3133451	112529

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14491.53 Da
• Isoelectric Point: 4.0763

>T35230 WP_182969249.1 NZ_AP022290:3053350-3053748 [Aeromonas veronii]
MDIIQFPPARVLEINHYILGASPGHQGPASIALLEGALGRIDNAIAYNGLDEVFLIAAKYAMAIGTAHAFSDANKRTGLA
VCLEYLSLNDFEIERDNEKLADAMVDLVLGELPEEWFADILYALWLEEQKTA

Nucleotide

• Length: 399 bp

>T35230 NZ_AP022290:3053350-3053748 [Aeromonas veronii]
ATGGATATCATCCAGTTTCCTCCCGCTCGGGTGCTGGAGATTAACCACTACATCCTAGGTGCGTCGCCTGGTCACCAGGG
CCCTGCCAGCATCGCGTTATTGGAGGGGGCGCTTGGCCGTATCGACAACGCCATCGCCTACAACGGGCTAGATGAAGTGT
TTCTCATCGCCGCAAAGTACGCTATGGCCATCGGTACCGCTCACGCCTTTTCCGATGCTAACAAGCGCACCGGGCTCGCT
GTCTGCCTTGAGTATCTCTCCCTCAACGACTTCGAGATTGAAAGAGATAACGAGAAGCTGGCGGACGCCATGGTTGACCT
TGTGCTTGGCGAGCTGCCAGAAGAGTGGTTTGCCGATATCCTTTACGCGCTTTGGTTAGAAGAGCAAAAAACCGCCTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6774.79 Da
• Isoelectric Point: 10.1555

>AT35230 WP_182969248.1 NZ_AP022290:3053171-3053350 [Aeromonas veronii]
MKDNSVSNKYGLPQVQNRPQIKAEKNLCLNGEEGRQIIKSETKLTLKTHEKTFTRLADM

Nucleotide

• Length: 180 bp

>AT35230 NZ_AP022290:3053171-3053350 [Aeromonas veronii]
ATGAAAGACAACTCCGTCAGCAACAAGTATGGATTGCCACAAGTGCAGAATCGGCCGCAAATCAAGGCTGAAAAGAACCT
GTGCCTGAACGGTGAAGAGGGCCGCCAGATCATCAAGTCTGAGACCAAGCTGACACTGAAGACCCACGAGAAGACCTTCA
CCCGTTTGGCTGATATGTAA