Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 2088..2635 Replicon plasmid pWP9-S17-ESBL-11_2
Accession NZ_AP022289
Organism Escherichia coli strain WP9-S17-ESBL-11

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag H7R47_RS25765 Protein ID WP_000969996.1
Coordinates 2354..2635 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0S0ZPX5
Locus tag H7R47_RS25760 Protein ID WP_032291093.1
Coordinates 2088..2357 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R47_RS25750 146..1177 + 1032 WP_000907863.1 replication initiation protein -
H7R47_RS25755 1875..2033 + 159 WP_038349023.1 hypothetical protein -
H7R47_RS25760 2088..2357 + 270 WP_032291093.1 hypothetical protein Antitoxin
H7R47_RS25765 2354..2635 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7R47_RS25770 2675..3523 + 849 WP_032291092.1 3'-5' exonuclease -
H7R47_RS25775 3839..4348 - 510 WP_032291091.1 hypothetical protein -
H7R47_RS25780 4404..5006 - 603 WP_000517687.1 hypothetical protein -
H7R47_RS25785 5359..6705 + 1347 WP_063118133.1 hypothetical protein -
H7R47_RS25790 7204..7506 - 303 WP_001245884.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..82448 82448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T35224 WP_000969996.1 NZ_AP022289:2354-2635 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T35224 NZ_AP022289:2354-2635 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10069.43 Da        Isoelectric Point: 8.0565

>AT35224 WP_032291093.1 NZ_AP022289:2088-2357 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLGCGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT35224 NZ_AP022289:2088-2357 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGGGTGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S0ZPX5

References