Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4086408..4087189 Replicon chromosome
Accession NZ_AP022274
Organism Enterobacter cloacae strain WP8-W19-CRE-02

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag H7R70_RS19720 Protein ID WP_100166398.1
Coordinates 4086408..4086899 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag H7R70_RS19725 Protein ID WP_042713858.1
Coordinates 4086896..4087189 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R70_RS19700 4082242..4082934 + 693 WP_100166559.1 response regulator -
H7R70_RS19705 4083050..4085185 - 2136 WP_182945931.1 ornithine decarboxylase -
H7R70_RS19710 4085367..4086080 + 714 WP_100166396.1 DUF554 domain-containing protein -
H7R70_RS19720 4086408..4086899 - 492 WP_100166398.1 GNAT family N-acetyltransferase Toxin
H7R70_RS19725 4086896..4087189 - 294 WP_042713858.1 DUF1778 domain-containing protein Antitoxin
H7R70_RS19730 4087291..4089084 - 1794 WP_100166399.1 hybrid sensor histidine kinase/response regulator -
H7R70_RS19735 4089081..4089713 - 633 WP_182945932.1 response regulator transcription factor -
H7R70_RS19740 4089889..4090203 + 315 WP_010435531.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17482.27 Da        Isoelectric Point: 7.2653

>T35179 WP_100166398.1 NZ_AP022274:c4086899-4086408 [Enterobacter cloacae]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQASGASRTFVCCGGDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLV
ASI

Download         Length: 492 bp

>T35179 NZ_AP022274:c4086899-4086408 [Enterobacter cloacae]
ATGATCTCTGCCCCAGAGCCGCTTCATGCCGGGCATATTCTTACTCCATTTTGCTGTGGGGTAGATTCGATGGATAACTG
GCTCAAGCAGCGGGCGATGAAGAATCAGGCCAGTGGTGCATCCCGTACCTTTGTCTGTTGTGGCGGAGATTCTAACGTAC
TGGCTTATTACTCGCTGGCGTCCAGCGCGGTCACAACGAATACTGCACCCGGTCGCTTTCGTCGCAATATGCCCGATCCC
ATCCCTGTTGTGGTGCTGGGACGCCTGGCGGTAGATCAGTCTCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCCGGGCTGCGGGTGATCCAGGTGGCCGAGACCATCGGCATCCGCGGAATGCTGGTTCATGCCCTGTCGGATGAAGCGC
GGGAATTTTATCTGCGGGTGGGGTTTGAGCCATCGCCGATGGATCCGATGATATTGATGGTGACGTTGGGGGATTTGGTG
GCGAGTATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10941.57 Da        Isoelectric Point: 9.9156

>AT35179 WP_042713858.1 NZ_AP022274:c4087189-4086896 [Enterobacter cloacae]
MPAANTMAVKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQAPAPN
AALRKTMQTPAPWEREK

Download         Length: 294 bp

>AT35179 NZ_AP022274:c4087189-4086896 [Enterobacter cloacae]
ATGCCAGCTGCAAACACTATGGCGGTGAAACGCGAAACTCTTAACCTGCGCATCAGGCCTGCCGAGCGAGATCTTATCGA
TCGGGCAGCGAAAGCGAGAGGGAAAAACCGCACTGACTTCGTGCTGGAAGCAGCCCGCGCTGCTGCGGAAGAGGCACTGA
TCGAACAACGCATCATAATGGCCGATCCAGAGGCTTATCAGGAATTTCTGGCTCGTCTGGATCAGGCTCCAGCACCTAAT
GCCGCACTGCGTAAAACGATGCAGACCCCTGCGCCGTGGGAGCGGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References