35164

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 62298..62960 Replicon chromosome
Accession NZ_AP022274
Organism Enterobacter cloacae strain WP8-W19-CRE-02

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H7R70_RS00305 Protein ID WP_182946139.1
Coordinates 62562..62960 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H7R70_RS00300 Protein ID WP_109081969.1
Coordinates 62298..62558 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R70_RS00275 57513..58634 - 1122 WP_029484915.1 efflux RND transporter periplasmic adaptor subunit -
H7R70_RS00280 58783..59352 - 570 WP_010426497.1 TetR/AcrR family transcriptional regulator -
H7R70_RS00285 59539..59958 + 420 WP_042714400.1 GNAT family N-acetyltransferase -
H7R70_RS00290 59955..60602 - 648 WP_042714401.1 TetR/AcrR family transcriptional regulator -
H7R70_RS00295 60696..62180 + 1485 WP_182946138.1 MFS transporter -
H7R70_RS00300 62298..62558 + 261 WP_109081969.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H7R70_RS00305 62562..62960 + 399 WP_182946139.1 type II toxin-antitoxin system VapC family toxin Toxin
H7R70_RS00310 63149..63949 + 801 WP_182946140.1 lipoprotein NlpA -
H7R70_RS00315 64045..64824 + 780 WP_182946141.1 MBL fold metallo-hydrolase -
H7R70_RS00320 64850..65803 + 954 WP_182946142.1 helix-turn-helix domain-containing protein -
H7R70_RS00325 65832..66920 - 1089 WP_042714408.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14766.00 Da        Isoelectric Point: 6.3267

>T35164 WP_182946139.1 NZ_AP022274:62562-62960 [Enterobacter cloacae]
MLHMLDTNIVSHLVRQHPEVLNQYSRIAPEKLCISSVTEAELLYGVAKKQNNQLHKTILEFLKTITICDWDSEAAAAYGE
LRAVMEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFGMVQDLRVEDWTTAA

Download         Length: 399 bp

>T35164 NZ_AP022274:62562-62960 [Enterobacter cloacae]
ATGCTGCATATGCTGGACACAAACATCGTAAGCCATCTGGTGAGGCAACACCCCGAGGTTCTAAATCAATATTCGCGTAT
CGCGCCTGAAAAATTGTGTATTTCAAGCGTAACAGAGGCTGAATTACTTTACGGCGTAGCCAAAAAGCAAAACAACCAAC
TGCACAAAACCATACTGGAATTTCTAAAAACCATCACCATTTGCGACTGGGACAGTGAAGCCGCAGCCGCCTACGGCGAG
CTTCGTGCAGTGATGGAAAAGAAAGGGAAGGTGATGGGCGATCTCGACCAGTTGATTGCTGCGCATGCCATCAGCCGGGG
TACGACGATTGTCACCAACGATCGTGCATTTGGGATGGTTCAAGACCTTAGGGTAGAGGACTGGACTACCGCAGCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10104.44 Da        Isoelectric Point: 9.6539

>AT35164 WP_109081969.1 NZ_AP022274:62298-62558 [Enterobacter cloacae]
MERTVKLIKKGRKQAVVLPAEFAFDTESVYIRRDDEGNIVLTARSEKERHRDNFLRLLKQTHVPDSFLSKEERNQSYSTR
DPLEGL

Download         Length: 261 bp

>AT35164 NZ_AP022274:62298-62558 [Enterobacter cloacae]
ATGGAGCGCACAGTAAAACTGATCAAAAAAGGGCGAAAGCAGGCTGTTGTTCTGCCTGCTGAGTTTGCGTTTGATACGGA
GAGCGTTTACATCCGGCGGGATGACGAGGGGAATATTGTTTTGACGGCAAGATCGGAAAAAGAGCGACACAGGGACAACT
TTTTGCGTTTACTCAAACAGACGCATGTGCCGGATTCGTTTCTGAGCAAAGAGGAGCGTAATCAGAGCTATTCGACACGA
GATCCTCTGGAAGGGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References