Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/ElaA-DUF1778 |
| Location | 78610..79349 | Replicon | plasmid pWP8-W19-CRE-01_1 |
| Accession | NZ_AP022269 | ||
| Organism | Raoultella ornithinolytica strain WP8-W19-CRE-01 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | H7R88_RS26235 | Protein ID | WP_076752153.1 |
| Coordinates | 78610..79095 (-) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A5E1AWX8 |
| Locus tag | H7R88_RS26240 | Protein ID | WP_012540086.1 |
| Coordinates | 79083..79349 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H7R88_RS26195 | 73800..74030 | - | 231 | WP_076752138.1 | hypothetical protein | - |
| H7R88_RS26200 | 74119..74466 | - | 348 | WP_076752140.1 | hypothetical protein | - |
| H7R88_RS26205 | 74569..74841 | - | 273 | WP_137055850.1 | hypothetical protein | - |
| H7R88_RS26210 | 75731..76147 | - | 417 | WP_076752145.1 | helix-turn-helix domain-containing protein | - |
| H7R88_RS26215 | 76144..76455 | - | 312 | WP_076752146.1 | type II toxin-antitoxin system HigB family toxin | - |
| H7R88_RS26220 | 76605..76817 | - | 213 | WP_076752148.1 | hypothetical protein | - |
| H7R88_RS26225 | 76925..77251 | - | 327 | WP_076752150.1 | hypothetical protein | - |
| H7R88_RS26230 | 78110..78268 | - | 159 | WP_076752152.1 | type I toxin-antitoxin system Hok family toxin | - |
| H7R88_RS26235 | 78610..79095 | - | 486 | WP_076752153.1 | GNAT family N-acetyltransferase | Toxin |
| H7R88_RS26240 | 79083..79349 | - | 267 | WP_012540086.1 | DUF1778 domain-containing protein | Antitoxin |
| H7R88_RS26245 | 79650..79973 | + | 324 | WP_013087171.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| H7R88_RS26250 | 79975..80688 | + | 714 | WP_013087170.1 | arsenical resistance protein ArsH | - |
| H7R88_RS26255 | 80697..81242 | + | 546 | WP_047365773.1 | sigma-70 family RNA polymerase sigma factor | - |
| H7R88_RS26260 | 81318..81680 | + | 363 | WP_013087168.1 | arsenic metallochaperone ArsD family protein | - |
| H7R88_RS26265 | 81707..83458 | + | 1752 | WP_175406650.1 | arsenical pump-driving ATPase | - |
| H7R88_RS26270 | 83583..84119 | + | 537 | WP_013087166.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaNDM-5 | - | 1..241445 | 241445 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17838.68 Da Isoelectric Point: 10.0748
>T35161 WP_076752153.1 NZ_AP022269:c79095-78610 [Raoultella ornithinolytica]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSRTQQRTLFLKLP
Q
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSRTQQRTLFLKLP
Q
Download Length: 486 bp
>T35161 NZ_AP022269:c79095-78610 [Raoultella ornithinolytica]
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTTATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACGAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTTATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACGAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10076.47 Da Isoelectric Point: 4.3721
>AT35161 WP_012540086.1 NZ_AP022269:c79349-79083 [Raoultella ornithinolytica]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV
Download Length: 267 bp
>AT35161 NZ_AP022269:c79349-79083 [Raoultella ornithinolytica]
ATGAAATCAGATGTTCAACTTAATCTTAGAGCAAAGGAATCACAGCGGGCGCTCATTGATGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAACGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA
ATGAAATCAGATGTTCAACTTAATCTTAGAGCAAAGGAATCACAGCGGGCGCTCATTGATGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAACGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|