Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1882204..1882794 Replicon chromosome
Accession NZ_AP022268
Organism Raoultella ornithinolytica strain WP8-W19-CRE-01

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag H7R88_RS08820 Protein ID WP_123629565.1
Coordinates 1882462..1882794 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag H7R88_RS08815 Protein ID WP_075808466.1
Coordinates 1882204..1882461 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R88_RS08790 1877609..1878805 - 1197 WP_048023855.1 MFS transporter -
H7R88_RS08795 1878802..1879197 - 396 WP_004864432.1 heme-binding protein -
H7R88_RS08800 1879295..1879999 - 705 WP_183114566.1 IclR family transcriptional regulator -
H7R88_RS08805 1880290..1881189 + 900 WP_015583965.1 alpha/beta hydrolase -
H7R88_RS08810 1881725..1881856 + 132 Protein_1724 helix-turn-helix domain-containing protein -
H7R88_RS08815 1882204..1882461 + 258 WP_075808466.1 antitoxin Antitoxin
H7R88_RS08820 1882462..1882794 + 333 WP_123629565.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H7R88_RS08830 1883119..1884555 + 1437 WP_004864427.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
H7R88_RS08840 1885064..1885873 - 810 WP_064359031.1 HAD-IIB family hydrolase -
H7R88_RS08845 1886073..1887527 - 1455 WP_004864423.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11783.65 Da        Isoelectric Point: 9.4051

>T35146 WP_123629565.1 NZ_AP022268:1882462-1882794 [Raoultella ornithinolytica]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSTASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTKTIGVIRCDQPRTI
DMAARNGMRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

>T35146 NZ_AP022268:1882462-1882794 [Raoultella ornithinolytica]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCCGGTCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGACGGCATCGTTTAACAAGCTAACCCGGCTACCCGTTGTTGTACCCGTCACCAGTGGTGGAAACTTTGCTCGCA
CGGCAGGTTTCACTGTTTCACTGGAAGGGGCGGGGACAAAAACAATAGGCGTGATTCGCTGCGACCAGCCCAGAACCATT
GATATGGCTGCCCGGAACGGCATGCGGCTGGAACGCATACCTGACGCCGTTGTAAATGAAGTGCTTGCCAGGCTAGATGC
GATTCTCAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9414.97 Da        Isoelectric Point: 4.4620

>AT35146 WP_075808466.1 NZ_AP022268:1882204-1882461 [Raoultella ornithinolytica]
MYTTRLKKVGGSIMLAVPPAVLKTLELSMGSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT35146 NZ_AP022268:1882204-1882461 [Raoultella ornithinolytica]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCCCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGATGGGCAGCGAAGTGGGTATGACTATTGATAATGGCTGCCTGATTATTGAACCTCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGTGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References