35142

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4836061..4837634 Replicon chromosome
Accession NZ_AP022264
Organism Aeromonas veronii strain WP8-S18-ESBL-11

Toxin (Protein)


Gene name hipA Uniprot ID A0A1Q8D8F8
Locus tag H7R84_RS22450 Protein ID WP_075112288.1
Coordinates 4836061..4837380 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1Q8D8F6
Locus tag H7R84_RS22455 Protein ID WP_042013334.1
Coordinates 4837380..4837634 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R84_RS22435 4831961..4832725 + 765 WP_182933220.1 ATP-binding cassette domain-containing protein -
H7R84_RS22440 4832744..4833670 + 927 WP_182933221.1 ABC transporter substrate-binding protein -
H7R84_RS22445 4833667..4835649 + 1983 WP_182933222.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
H7R84_RS22450 4836061..4837380 - 1320 WP_075112288.1 type II toxin-antitoxin system HipA family toxin Toxin
H7R84_RS22455 4837380..4837634 - 255 WP_042013334.1 helix-turn-helix domain-containing protein Antitoxin
H7R84_RS22460 4837804..4838232 - 429 WP_075112289.1 DUF86 domain-containing protein -
H7R84_RS22465 4838225..4838674 - 450 WP_075112290.1 nucleotidyltransferase domain-containing protein -
H7R84_RS22470 4839121..4839744 + 624 WP_042878565.1 recombinase family protein -
H7R84_RS22475 4840286..4841017 - 732 WP_182934330.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49366.38 Da        Isoelectric Point: 7.0150

>T35142 WP_075112288.1 NZ_AP022264:c4837380-4836061 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDGELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLFLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGIPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDAISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

>T35142 NZ_AP022264:c4837380-4836061 [Aeromonas veronii]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCATGGCTGGCACAACCGGGCAGCCGTCCCATCTCACTTTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACTCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGACGTTCCAGATGTCAGGCGAATCGACTACAAAGCACTTTCCGATGGCGAGCTCGAGCAGATTCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGAGCGCAAGAAAAGACAGCG
CTGCTCTTTCTCGATGGCCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATTGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTATACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGTCATGGAGGACCAGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAATACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCGAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGTGTTACCCAGCAATTGCCAGCGGGCTTCCCCGATGCCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9323.64 Da        Isoelectric Point: 7.9834

>AT35142 WP_042013334.1 NZ_AP022264:c4837634-4837380 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILASLELSLDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp

>AT35142 NZ_AP022264:c4837634-4837380 [Aeromonas veronii]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAACTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCATCACTCGAATTGTCACTGGACATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q8D8F8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8D8F6

References