Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2199383..2201090 Replicon chromosome
Accession NZ_AP022264
Organism Aeromonas veronii strain WP8-S18-ESBL-11

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag H7R84_RS10020 Protein ID WP_182934094.1
Coordinates 2199383..2200309 (-) Length 309 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag H7R84_RS10025 Protein ID WP_182934277.1
Coordinates 2200302..2201090 (-) Length 263 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R84_RS10005 2195407..2197740 + 2334 WP_182934091.1 DEAD/DEAH box helicase family protein -
H7R84_RS10010 2198147..2198365 + 219 WP_182934092.1 Com family DNA-binding transcriptional regulator -
H7R84_RS10015 2198277..2199335 + 1059 WP_182934093.1 site-specific DNA-methyltransferase -
H7R84_RS10020 2199383..2200309 - 927 WP_182934094.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
H7R84_RS10025 2200302..2201090 - 789 WP_182934277.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
H7R84_RS10030 2201378..2201590 + 213 WP_182934095.1 hypothetical protein -
H7R84_RS10035 2201590..2202081 + 492 WP_182934096.1 lysozyme -
H7R84_RS10040 2202087..2202626 + 540 WP_182934278.1 DUF2514 domain-containing protein -
H7R84_RS10045 2202712..2203092 + 381 WP_182934097.1 HNH endonuclease -
H7R84_RS10050 2203188..2203673 + 486 WP_182934098.1 phage terminase small subunit P27 family -
H7R84_RS10055 2203683..2205404 + 1722 WP_182934099.1 terminase large subunit -
H7R84_RS10060 2205398..2205586 + 189 WP_139462619.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2176599..2217738 41139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(15-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 35136.56 Da        Isoelectric Point: 4.8646

>T35141 WP_182934094.1 NZ_AP022264:c2200309-2199383 [Aeromonas veronii]
MNKDSVYYRQVQLLLKMLPIIANEKMFALKGGTAINLFVREFPRLSVDIDLSYLQLEPREEAIANVRAALHRIVEQTNKQ
QGLQARLQDNNGDELRIIVTGAATIKIELSPVARGTLHDPEVLPVVEDVETEFGYAEIAVVSMPDLYGGKLCAAMDRQHP
RDLFDVRMLLAAEGITREIFVGFLAYTLGHPRPISEVMDPRWKDLSDAFQQEFEGMTNEPVTLEELLEVPEAMFAALKAQ
FTPRDKDFLLSFKRGEPDWTLFDVPTAERLPAIRWKLQNLQKLRDKNPEKHQEALVKLDKVLTAWLVE

Download         Length: 927 bp

>T35141 NZ_AP022264:c2200309-2199383 [Aeromonas veronii]
ATGAATAAAGACTCCGTCTATTACCGACAGGTACAATTACTGCTCAAGATGCTGCCAATCATCGCCAATGAGAAGATGTT
TGCCCTAAAAGGGGGAACTGCTATCAATCTTTTTGTACGTGAGTTCCCCCGACTGTCTGTTGATATCGATTTATCTTATC
TGCAACTCGAGCCTCGAGAAGAAGCGATAGCCAATGTCAGGGCCGCATTGCATCGGATTGTAGAACAAACGAATAAGCAA
CAAGGCCTACAAGCCCGTCTTCAAGACAATAACGGGGATGAACTCAGGATTATCGTCACAGGAGCTGCGACGATCAAAAT
CGAACTCTCGCCAGTTGCTCGAGGTACACTACATGACCCCGAAGTGCTTCCTGTGGTTGAAGATGTCGAAACTGAGTTTG
GCTACGCCGAAATAGCAGTTGTCAGCATGCCTGACCTTTACGGGGGCAAACTCTGTGCTGCAATGGACAGACAACACCCA
CGGGATCTGTTTGATGTCCGAATGCTATTGGCTGCAGAGGGGATAACCCGGGAGATATTTGTGGGCTTCCTCGCTTACAC
TCTGGGCCATCCCAGACCGATCAGCGAAGTAATGGACCCAAGATGGAAAGATCTCTCTGACGCGTTTCAACAGGAGTTTG
AAGGGATGACTAACGAGCCCGTCACCTTGGAGGAGCTGCTTGAAGTCCCCGAAGCAATGTTTGCCGCTTTAAAAGCCCAG
TTTACCCCACGCGATAAAGACTTTCTCCTATCCTTCAAACGAGGAGAGCCTGACTGGACACTGTTTGATGTACCTACCGC
TGAGCGGTTACCCGCGATTCGTTGGAAACTACAAAATTTGCAAAAACTACGAGACAAGAACCCTGAAAAACATCAAGAGG
CATTGGTCAAACTCGACAAGGTCTTAACGGCATGGCTTGTTGAATAG

Antitoxin


Download         Length: 263 a.a.        Molecular weight: 29700.80 Da        Isoelectric Point: 9.5423

>AT35141 WP_182934277.1 NZ_AP022264:c2201090-2200302 [Aeromonas veronii]
ISSKINWLANHAPPGSLVLQPWLIENGISYSLASKYANSGWLKKMTNGVYYRPNPYQNSLPDWTDALAAITNQLNRHPHI
AGLTSLKYQGLSHYLQLGKEQVWLGGESKSSLPAWFREFDCSPWLFIGTSKLAAQSEKDFTLITVQGKELRASCPELAAY
EVVNTIGKHISFEHAAELFQGLTNLSPRKVQSILTRSKAVQTNRVFLFLSHYYRHQWTKRLDETQITLGTGKRQVVAQGR
LEPRYQITVPEPFFVASEIDHE

Download         Length: 789 bp

>AT35141 NZ_AP022264:c2201090-2200302 [Aeromonas veronii]
ATATCATCAAAGATAAACTGGCTAGCCAACCACGCCCCACCCGGTTCGTTGGTGCTGCAACCATGGCTCATAGAAAACGG
TATCAGCTACTCCTTGGCATCTAAGTATGCAAACAGCGGTTGGTTGAAAAAAATGACCAACGGCGTCTACTACCGCCCTA
ATCCCTATCAGAATTCACTACCTGATTGGACTGATGCTCTCGCAGCCATCACCAATCAACTGAATCGCCATCCCCACATA
GCAGGTCTCACAAGCCTGAAATACCAAGGACTAAGTCACTATCTGCAACTCGGAAAAGAGCAGGTCTGGCTCGGTGGTGA
GAGTAAGAGCTCTCTCCCAGCATGGTTTCGTGAGTTTGACTGCTCACCCTGGTTGTTTATCGGCACATCGAAACTGGCGG
CGCAAAGCGAAAAAGATTTCACACTGATCACTGTACAGGGCAAAGAACTCCGAGCCAGCTGCCCCGAACTCGCCGCTTAT
GAGGTCGTCAACACGATAGGTAAACATATCAGCTTTGAACACGCAGCGGAGCTGTTTCAAGGCTTGACCAATTTGAGTCC
TCGTAAAGTGCAATCCATATTGACACGGAGCAAGGCAGTCCAAACCAATCGGGTATTTCTTTTTCTCTCCCATTATTATC
GCCATCAGTGGACAAAGAGACTCGATGAAACCCAGATCACATTGGGAACCGGCAAACGCCAAGTTGTCGCACAAGGGCGG
TTAGAACCTCGCTATCAAATAACCGTGCCAGAACCTTTTTTCGTAGCATCAGAGATCGATCATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References